Nexlizet (Bempedoic acid/Ezetimibe) is typically prescribed to reduce the risk of heart attack and on certain heart procedures, such as stent placement or bypass surgery helps to open blocked arteries, in individuals with heart disease or those at high risk for heart disease and to reduce LDL cholesterol (bad cholesterol) levels in people with heterozygous familial hypercholesterolemia, a genetic condition that affects the body's ability to remove cholesterol from the blood.

Nexlizet lowers cholesterol by reducing its production in the liver, promoting the breakdown of LDL ‘bad’ cholesterol, and blocking the absorption of cholesterol in the intestines. While Ezetimibe blocks the absorption of cholesterol.

Only take Nexlizet if it has been prescribed by your doctor and the usual dose is once a day. Follow the prescribed dosage instructions. Do not cut, crush, or chew the Nexlizet tablets.

If you miss a dose, take it as soon as you remember yet if it's nearly time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not take two doses at the same time.

Before starting Nexlizet, discuss your medical history with your doctor. Nexlizet may not be suitable for you if you have certain health conditions or other factors that could affect your well-being. These include:

Gout: Nexlizet may increase uric acid levels, which can lead to gout. If you have a history of gout, you may be at higher risk while taking Nexlizet. Be sure to inform your doctor if you experience sudden pain, swelling, redness, or a change in color in your joints while on the medication. If these symptoms occur, your doctor may prescribe treatments to help lower your uric acid levels.

Tendon problems:Your risk of this side effect may be increased if you have a history of tendon problems. Before starting Nexlizet, inform your doctor if you've had tendon issues in the past. In such cases, they may suggest an alternative treatment to manage your cholesterol levels.

Kidney problems: Your risk for this side effect may be increased if you have kidney issues, such as kidney failure. If you have kidney problems, consult your doctor to determine if Nexlizet is safe for you to use.

Liver problems: Nexlizet may cause elevated liver enzymes, which could indicate liver dysfunction. If you have liver issues, such as liver failure, taking Nexlizet may worsen these conditions. Discuss with your doctor whether it is safe for you to use Nexlizet if you have liver problems.

Allergic reaction: If you have had an allergic reaction to Nexlizet or any of its ingredients, you should not take this medication. Talk to your doctor about alternative treatments that may be more suitable for you.

If you experience any side effects that are bothersome or do not go away, contact your doctor. There is no evidence to suggest that Nexlizet causes weight loss or weight gain.

Common side effects may include:
• Colds
• Diarrhea
• Increased liver enzymes
• Lung infection
• Back pain
• High uric acid levels
• Low red blood cell levels
• Stomach pain
• Tiredness
Serious side effects may include:
• Hyperuricemia or Increased levels of uric acid in your blood- This may occur within 4 weeks of starting Nexlizet
• Tendon rupture or injury: Tendon issues may occur in people taking bempedoic acid, one of the active ingredients in Nexlizet.If you experience any signs or symptoms of a tendon rupture, stop taking Nexlizet immediately and seek medical help right away
• Allergic reactions. Ezetimibe component of Nexlizet may cause hypersensitivity reactions, such as anaphylaxis, angioedema, or hives. Do not use Nexlizet if you have a known allergy to ezetimibe. If you experience any signs of an allergic reaction, stop taking Nexlizet immediately and contact your doctor, or go to the nearest emergency room.

These are not all the potential side effects of Nexlizet. For more information, consult your doctor or pharmacist.

Is it safe to take it with another drug?

Nexlizet can interact with other medications, and vice versa. Inform your doctor about all the medicines you are taking. Inform your doctor if you are taking or plan to take:

• Cholestyramine (a medication used to lower cholesterol)
• Fibrates (medications used to reduce cholesterol levels)
• Cyclosporine (commonly prescribed to organ transplant recipients)
• Simvastatin or pravastatin (other medications used to lower cholesterol)
Taking Nexlizet with simvastatin or pravastatin may increase your risk of muscle pain or weakness (myopathy).

Be aware of the medications you are taking. Keep a list to share with your doctor and pharmacist whenever you start a new medication.

How should I store it?

Nexlizet should be stored at room temperature, between 20°C and 25°C. It can tolerate brief exposure to temperatures ranging from 15°C to 30°C, such as during transportation. Keep the medication in a cool, dry place.

What action should I take in case of overdose?

If you or someone else has taken too much Nexlizet or experienced serious side effects seek medical assistance immediately by contacting your doctor or going to the emergency department.

Is it safe for pregnant or breastfeeding women?

Nexlizet may be harmful to an unborn baby. Inform your doctor if you are pregnant or planning to become pregnant. It is unknown whether Nexlizet passes into breast milk. Let your doctor know if you are breastfeeding or intend to breastfeed.

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