NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Nubeqa prescribed?

Nubeqa (Darolutamide) is prescribed for treating two types of prostate cancer: non-metastatic castration-resistant prostate cancer (nmCRPC), which has not spread and does not respond to treatments that lower testosterone, and metastatic hormone-sensitive prostate cancer (mHSPC), which has spread and responds to such treatments, often in combination with docetaxel.

What does it do?

Nubeqa (Darolutamide) works by targeting androgen receptors in prostate cancer cells. Androgens, like testosterone, fuel the growth of prostate cancer. Nubeqa blocks these receptors, preventing androgens from binding to them. This action disrupts the signals that promote cancer cell growth and survival, effectively slowing down or stopping the progression of the disease.

How should I take it?

Take Nubeqa exactly as your doctor prescribes. Carefully follow the instructions on your prescription label and thoroughly review any medication guides or instruction sheets provided. The recommended dose is two (2) 300 mg tablets, twice daily (600 mg per dose) and taken with food. Swallow the whole tablet without crushing, chewing, or breaking it. If you're also undergoing other therapies, like GnRH treatment, follow your doctor’s guidance closely.

What if I missed a dose?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

What are the special precautions before taking Nubeqa?

Before starting Nubeqa (Darolutamide), here are some important precautions to consider:

• Tell your healthcare provider if you have a history of liver or kidney problems, as these conditions may affect how the drug is processed in your body.
• Share a complete list of all medications, supplements, and over-the-counter products you're taking, as Nubeqa can interact with other drugs and potentially alter their effectiveness or cause side effects.
• Do not share Nubeqa with others, even if they have the same condition, as it could potentially be harmful to them.
• Nubeqa is not safe for use by women during pregnancy, as it could harm an unborn baby. Inform your doctor immediately if a pregnancy occurs while using Nubeqa.
• If you have a history of seizures or conditions that increase seizure risk, inform your healthcare provider, as Nubeqa may heighten this risk.
• Let your doctor know if you have any heart conditions, as Nubeqa may cause or worsen heart problems.

Always inform your doctor about all the medications you are taking, your current and previous medical history.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Fatigue
• Pain or discomfort in the hands, arms, legs, or feet
• Skin rash
• Constipation
• Weight gain

Serious side effects may include:
• Dizziness, feeling lightheaded, or fainting
• Severe headache
• Seizures
• Heart and breathing problems
• High blood pressure
• Swelling of the face, lips, mouth, tongue, or throat

This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Make sure that you discuss with your healthcare provider if you are taking any of the following medications:

The following drugs affects Nubeqa:

• Carbamazepine
• Rifampin
• Dexamethasone
• St. John’s wort
• Clarithromycin
• Diltiazem
• Itraconazole
• Ketoconazole

The following drugs Nubeqa affects:

• Atorvastatin
• Digoxin
• Rosuvastatin
• Simvastatin
• Enalapril
• Valsartan

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Nubeqa (Darolutamide) should be stored at room temperature between 20°C and 25°C (68°F and 77°F) in its original container to protect it from moisture. Keep it away from direct sunlight and out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Nubeqa (Darolutamide), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital.

Is it safe for pregnant or breastfeeding women?

Nubeqa (Darolutamide) is not safe for use during pregnancy or breastfeeding. It is not recommended for use during pregnancy as it can harm an unborn baby or cause pregnancy loss. Male patients with partners who can become pregnant are advised to use effective contraception during treatment and for at least one week after the last dose. On the other hand, the safety of Nubeqa during breastfeeding has not been established. It is unknown whether the drug passes into human milk or if it affects the milk production.

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