Why is Osphena prescribed?

Ospemifene (Osphena) is prescribed for the treatment of dyspareunia (painful sexual intercourse) and to relieve vaginal dryness in women going through menopause (a time of life marking the end of a woman’s menstrual cycles).

What does it do?

Dyspareunia during menopause is due to low estrogen levels causing insufficient lubrication in the vagina. The pain felt during intercourse can be moderate to severe in intensity. Ospemifene is classified as a hormone that primarily works by taking the place of estrogen in the body to restore changes in the vaginal tissue, controlling the symptoms of menopause causing painful intercourse and vaginal dryness.

How should I take it?

Osphena and its generic equivalents are currently available as 60mg tablets. Each tablet should be taken as a whole (do not split) by mouth with food.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only use this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Osphena?

Before taking Ospemifene, tell your doctor or pharmacist if you have any allergies to food or to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

Inform your doctor about your past and current medical history especially if you have or have had liver disease, breast cancer, diabetes, high blood pressure, high cholesterol levels, or lupus.

Taking Ospemifene can make you susceptible to the formation of blood clots, having a stroke, or heart attacks. Consult your doctor regarding this risk.

For the drug label information of Osphena, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Headache
• Hot flashes
• Increased sweating
• Muscle spasms
• Night sweats
• Vaginal bleeding
• Vaginal discharge

Serious side effects include:
• Balance problems
• Chest pain
• Coughing up blood
• Difficulty breathing
• Severe headache
• Slurred speech
• Swelling in an arm or leg
• Unusual vaginal bleeding

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Osphena with any of the following medications:

• Acetaminophen
• Ambrisentan
• Amprenavir
• Apalutamide
• Atazanavir
• Biaxin
• Boceprevir
• Bosentan
• Carbatrol
• Carfilzomib
• Ceritinib
• Chlorotrianisene
• Clofarabine
• Clomid
• Conivaptan
• Cordarone
• Dapagliflozin
• Delavirdine
• Diane
• Diethylstilbestrol
• Diflucan
• Dilantin
• Enzalutamide
• Evista
• Glucophage
• Guanfacine
• Indinavir
• Isoniazid
• Jardiance
• Lenalidomide
• Luvox
• Miconazole
• Nefazodone
• Ogen
• Pomalidomide
• Thalidomide
• Tranexamic acid
• Xenical
• Zafirlukast

If you are using any prescription, non-prescription, and herbal medications, inform your doctor and pharmacist for proper information and ask for other possible interactions not listed within this section.

How should I store it?

Store Osphena at room temperature (25°C) in a clean environment away from light and moisture, as well as children and pets. Do not refrigerate. Do not remove the desiccant in the original container. Throw away if unused or expired. Do not flush in the toilet. Consult the pharmacist for proper disposal.

What action should I take in case of overdose?

Call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Ospemifene to determine drug-associated risks of major maternal defects, miscarriages, and fetal outcomes.

Limited data have been established indicating the presence of Ospemifene in human milk. Consult your doctor first before breastfeeding.

The use of Ospemifene in pregnant and breastfeeding women should be carefully evaluated to determine if its potential benefits outweigh the risks.

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