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Why is Otezla prescribed?

Otezla contains the active ingredient apremilast, which is a type of medication known as a phosphodiesterase 4 (PDE4) inhibitor. It works by helping to reduce inflammation.

What does it do?

Otezla (Apremilast) is used to treat plaque psoriasis, psoriatic arthritis, and Behçet's disease in certain patients. The tablets work by blocking the phosphodiesterase type 4 (PDE4) enzyme, helping to improve plaque psoriasis for clearer skin and reducing inflammation, pain, redness, and swelling associated with psoriatic arthritis and Behçet's disease.

How should I take it?

Take Otezla exactly as your doctor tells you to. This medication can be taken with or without food. The dose of Otezla is typically gradually increased during the first week to minimize potential gastrointestinal side effects that may occur when starting the medication. Please note that specific dosage adjustments are necessary in cases of severe renal impairment.

What if I missed a dose?

If you miss a dose of Otezla, talk to your doctor about when you will take it again. This medication has to be taken in titration dosing.

What are the special precautions before taking Otezla?

Otezla (Apremilast) can lead to serious health problems, and the risk may be higher for certain individuals. If you are concerned, discuss alternative options with your doctor or pharmacist.

Allergic reaction: In rare cases, Otezla (Apremilast) may cause a severe allergic reaction. If you develop hives, difficulty breathing, or swelling of your lips, tongue, or throat, stop taking the medication and seek medical attention immediately.

Diarrhea, nausea, and vomiting: Nausea, vomiting, and diarrhea are common side effects when you begin taking Otezla (Apremilast). Although these effects typically improve over time, they can be severe and may lead to dehydration (a loss of fluids in the body). Older adults and individuals taking diuretics or other medications that remove fluid are at higher risk for dehydration.

Depression: Some individuals taking Otezla (Apremilast) have reported experiencing depression or feelings of sadness. Before starting Otezla, inform your healthcare provider if you have a history of depression or have ever had thoughts of suicide.

Weight loss: Keep a close watch on your weight while taking Otezla (Apremilast). In clinical studies, up to 12% of individuals using Otezla experienced unexplained weight loss.

Does it have any side effects?

The following side effects may improve as your body adjusts to the medication. However, inform your doctor right away if these symptoms persist or worsen.

Common side effects may include:
• Diarrhea
• Headache
• Upper respiratory tract infection
• Nausea
• Stomach pain
• Tiredness
• Vomiting
Serious side effects may include:
• Depression
• Thoughts of self-harm
• Severe allergic reaction
If you are 65 years or older, you may be at a higher risk for complications from severe diarrhea, nausea, and vomiting. If you experience severe gastrointestinal issues, it is important to consult your doctor.
Is it safe to take it with another drug?

When taking Otezla, it’s important to inform your doctor about all the medications you are currently using, as well as any new medications you start or stop. This is particularly important if you are taking any of the drugs listed below. The following interactions are highlighted due to their potential significance, though they may not include all possible interactions.

Using Otezla with any of the following medications may not be recommended, but could be necessary in some cases. If both medications are prescribed together, your doctor may adjust the dose or frequency of one or both drugs

• Carbamazepine
• Fosphenytoin
• Enzalutamide
• Mitotane
• Phenytoin
• Primidone
• Rifampin
• Rifabutin
• Rifapentine
• St John's Wort
• Tofacitinib

This list is not exhaustive, and many other medications may interact with Otezla, including prescription and over-the-counter drugs, vitamins, and herbal supplements. Be sure to provide your doctor with a complete list of all the medications you are taking.

How should I store it?
Store below 30°C. Do not use this medicine after the expiry date. Keep out of the reach of children.
What action should I take in case of overdose?

If you take more Otezla than prescribed, seek medical attention immediately or go to the nearest hospital.

Is it safe for pregnant or breastfeeding women?

If you are pregnant, breastfeeding, planning to become pregnant, or think you may be pregnant, consult your doctor or pharmacist for advice before using this medication. There is limited information on the effects of Otezla during pregnancy. You should avoid becoming pregnant while taking this medicine and use an effective form of contraception throughout treatment with Otezla.

It is unknown whether Otezla passes into breast milk. Therefore, you should not use Otezla while breastfeeding.

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