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Why is Oxsoralen prescribed?

Oxsoralen, which contains Methoxsalen, is prescribed for its ability to enhance the skin's sensitivity to ultraviolet A (UVA) light. It is primarily used in combination with controlled UVA light therapy to treat conditions such as Vitiligo, Psoriasis, or Cutaneous T-cell lymphoma (CTCL).

What does it do?

Oxsoralen (Methoxsalen) becomes activated by ultraviolet A (UVA) light and interacts with DNA, which helps inhibit or halt the growth of abnormal skin cells. The therapeutic effects of Oxsoralen include DNA damage that helps regulate the excessive production of skin cells seen in psoriasis. It also stimulates melanocytes to repopulate skin affected by vitiligo and assists in controlling abnormal skin cell growth in cutaneous T-cell lymphoma.

How should I take it?

The dosage of Oxsoralen (methoxsalen) is usually based on your weight and medical condition, and your doctor will determine the appropriate dose for you. Take the medication 1.5 to 4 hours before your scheduled UVA light therapy, as directed by your doctor.

For at least 8 hours after taking Oxsoralen, avoid direct sunlight exposure until your UVA therapy, and wear protective clothing to prevent unintended photosensitivity reactions. Additionally, you should wear UVA-blocking sunglasses and sunscreen during daylight hours for at least 24 hours after taking the medication to protect your eyes and skin.

What if I missed a dose?

If you miss a dose of Oxsoralen (Methoxsalen), here’s what you should do:

• If your next scheduled UVA therapy is still hours away, take the missed dose as soon as you remember.
• If it’s almost time for your next dose or UVA therapy, skip the missed dose and continue with your regular schedule.
• Do not take two doses at once to make up for the missed dose, as this could increase the risk of side effects.
• If you miss an Oxsoralen (Methoxsalen) and UVA light treatment session, contact your healthcare provider promptly to reschedule the appointment.

What are the special precautions before taking Oxsoralen?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Before taking Oxsoralen, here are several important precautions to keep in mind:

• Do not take Oxsoralen if you are allergic to Methoxsalen or any of the other ingredients in the medication.
• Inform your doctor if you have a history of skin cancer, sensitivity to sunlight, or any other medical conditions that may affect your treatmentAvoid sharing this medication with others, even if they have the same condition, as it might cause harm or unintended side effects.
• Avoid direct sunlight or artificial UV light exposure for at least 24 hours before and after taking the medication to prevent severe burns or photosensitivity reactions.
• Wear UVA-blocking sunglasses and sunscreen during daylight hours for at least 24 hours after taking the medication to protect your eyes and skin.
• Consult your doctor if you are pregnant or breastfeeding, as the safety of Oxsoralen in these conditions is not well-established.
• Oxsoralen (Methoxsalen) is not recommended for children under 12 years of age.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Nausea or upset stomach
• Mild itching
• Redness of the skin
• Sensitivity to sunlight (photosensitivity)

Serious side effects may include:
• Severe burns or blistering of the skin due to overexposure to UVA or sunlight
• Increased risk of skin cancer with prolonged use
• Difficulty breathing
• Severe itching
• Swelling of the face, tongue, or throat

This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Oxsoralen (Methoxsalen) may interact with other medications, so it's important to take caution before combining it with other drugs. Oxsoralen may increase your skin's sensitivity to sunlight, particularly when combined with certain other medications such as:

• Anthralin
• An antibiotic or a sulfa drug
• Certain antimicrobial soaps
• Diuretic or "water pill";
• Coal tar applied to the skin or scalp
• Phenytoin

This list is not complete, as Oxsoralen can interact with various other drugs, including prescription medications, over-the-counter products, vitamins, and herbal supplements. Always seek medical advice from your healthcare provider before using Oxsoralen alongside other medications to ensure it is safe and effective.

How should I store it?

Oxsoralen should be stored in its original container at room temperature, ideally between 15°C and 30°C (59°F to 86°F). Keep it away from direct sunlight and out of reach of children and pets. Always refer to the medication's packaging for any specific storage guidelines and avoid using it beyond the expiration date.

What action should I take in case of overdose?

If you suspect an overdose of Oxsoralen (Methoxsalen), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Symptoms of overdose may include severe skin burns, blisters, or photosensitivity reactions.

Is it safe for pregnant or breastfeeding women?

The safety of Oxsoralen (Methoxsalen) for pregnant or breastfeeding women is not well established. This medication should only be used during pregnancy if the potential benefits outweigh the risks. While for breastfeeding women, it is not known whether the drug passes into breast milk or if it affects the breastfed child.

It's important to consult your doctor if you're pregnant or breastfeeding before using the medication to ensure safety.

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