NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Parnate prescribed?

Parnate contains the active ingredient tranylcypromine, which is part of a class of antidepressants known as monoamine oxidase inhibitors (MAOIs). This drug is used to treat moderate to severe depression in adults. Please note that Parnate is not the primary choice for Major Depressive Disorder due to its known serious adverse interactions.

What does it do?

Parnate works by preventing the breakdown of two chemicals in the brain, serotonin and noradrenaline, helping to restore their normal levels. This medication can also assist if you're experiencing feelings of fear (phobia), which can sometimes accompany depression. It is typically used when other antidepressant treatments have not been effective.

How should I take it?

Take this medication by mouth, with or without food, typically once or twice a day as prescribed by your doctor. The dosage depends on your medical condition and how you respond to the treatment.

What if I missed a dose?

If you miss to take Parnate, take it as soon as you remember. If it's within 2 hours of your next dose, skip the missed dose and take your next dose at the usual time. Do not take two doses at once.

What are the special precautions before taking Parnate?

Are allergic to tranylcypromine or any of the other ingredients in Parnate.

• Are currently taking or have taken other MAOIs in the past two weeks.
• Have taken clomipramine or imipramine in the last three weeks or plan to take them within the next three weeks.
• Have porphyria, a hereditary condition affecting the nervous system and skin.
• Have severe heart disease or any issues with the blood vessels in the brain.
• Have pheochromocytoma, a tumor of the adrenal glands causing high blood pressure.
• Diagnosed with an overactive thyroid gland.
• Liver problems or a blood cell disorder (your doctor will be aware of this).

Please inform your doctor if any of the above apply to you, and do not take this medication.

Parnate Tablets with drink, food, and alcohol: You should NOT consume alcohol (especially red wine) while taking Parnate Tablets, including non-alcoholic beer, lager, or wine. Parnate Tablets prevent the breakdown of a substance called tyramine, which is found in large amounts in certain foods. If tyramine is not broken down properly, it can lead to dangerously high blood pressure (hypertensive crisis).

While taking Parnate Tablets, you should avoid the following foods:
• Cheese, both cooked and plain such as processed or cheddar cheese made from mature cheese.
• Yeast extracts such as Bovril, Oxo, Marmite, brewer’s yeast.
• Fish, meat or poultry that is not fresh or has been pickled or aged such as pickled herring or hung game.
Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Chills
• Constipation
• Diarrhea
• Drowsiness
• Dry mouth
• Nausea
• Numbness
• Restlessness
• Regular headaches
• Sensitivity to light
• Stomach pain
• Vision problems
• Weakness

Serious side effects may include: Is the risk of hypertensive crises, which can be life-threatening. If you experience any of the following serious side effects, seek immediate medical attention or go to the nearest emergency department.
• Severe eye symptoms such as sudden vision loss, tunnel vision, blurred vision, eye pain or swelling, or seeing halos around lights.
• Serious heart symptoms such as rapid, pounding or irregular heartbeats; fluttering in your chest; shortness of breath; lightheadedness, sudden dizziness, or fainting.
• Severe headache, slurred speech, confusion, weakness in the arms or legs, loss of coordination, difficulty walking, unsteadiness, high fever, very stiff muscles, excessive sweating, or tremors.
This document does not list all possible side effects; others may occur. Consult your physician for more information about potential side effects.
Is it safe to take it with another drug?
Inform your doctor or pharmacist if you are taking, have recently taken, or plan to take any other medications, including those obtained without a prescription.

Do not take Parnate with the following medications:

• Dopamine, used for certain heart conditions
• Sympathomimetic agents, such as ephedrine, pseudoephedrine, adrenaline, and noradrenaline (found in medications for heart issues, decongestants, asthma, and cough or cold treatments)
• Bupropion, used to help quit smoking
• Buspirone, used to treat anxiety
• Appetite suppressants, such as amphetamine and fenfluramine
• Medications for Parkinson's disease, such as levodopa
• Pain relievers like pethidine and nefopam
• General anesthetics like propofol used in surgery
• Other antidepressants, such as amitriptyline, imipramine, and tryptophan
• Metrizamide, a nonionic radiopaque contrast agent

Parnate Tablets should be taken with caution if you are using the following medications:

• Antihistamines for allergies, such as cetirizine
• Strong painkillers, such as codeine
• Medications for diabetes, such as insulin or metformin
• Medications for seizures, such as carbamazepine
• Barbiturates for severe sleep issues, such as amylobarbitone
• SSRIs, like fluoxetine or sertraline (for depression). Taking Parnate with these medications may lead to serious side effects, including sweating, severe agitation, confusion, and muscle stiffness
• Medications for high blood pressure, such as guanethidine, reserpine, or methyldopa
• Other MAOIs, such as Isocarboxazid
Ask your doctor or pharmacist for other possible interactions not listed within this section.
How should I store it?
Store between 15°C and 30°C Keep in a tightly closed, light-resistant container. Keep out of reach of children.
What action should I take in case of overdose?
If you believe that you or someone else has taken too many tablets, Overdose symptoms include severe headache, weakness and sleep problems contact your doctor or go to the nearest hospital emergency department immediately.
Is it safe for pregnant or breastfeeding women?
If you are pregnant, breastfeeding, planning to become pregnant, or think you may be pregnant, consult your doctor or pharmacist before using this medication. Parnate should not be used during pregnancy or breastfeeding unless your doctor determines it is absolutely necessary, as this medicine may pass into breast milk.

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