NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Pennsaid prescribed?

Pennsaid, which contains Diclofenac Sodium as its active ingredient, is a topical nonsteroidal anti-inflammatory drug (NSAID). It is primarily prescribed for the treatment of pain associated with osteoarthritis of the knees. By reducing inflammation, it helps alleviate symptoms like swelling, stiffness, and discomfort.

What does it do?

In summary, Pennsaid works by inhibiting enzymes called cyclooxygenase (COX). These enzymes are responsible for producing prostaglandins, which are substances in the body that cause pain and inflammation. By reducing prostaglandin production, Pennsaid helps reduce pain and inflammation, particularly in the knees affected by osteoarthritis.

How should I take it?

Pennsaid should be used exactly as prescribed by your doctor. Here are some general guidelines to keep in mind:

• Apply 40 mg of diclofenac sodium (2 pump actuations) to each affected knee, twice daily. Dispense the solution into your hand and spread it evenly around the front, back, and sides of the knee.
• Avoid applying it to open wounds or irritated skin.
• Wash your hands after application unless you're treating your hands and avoid showering or bathing for at least 30 minutes after applying the medication.
• Protect the treated area from sunlight and avoid using other topical products on the same area until it is dry.

What if I missed a dose?

If you miss a dose of Pennsaid, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed one and continue with your regular schedule. Avoid applying extra amounts to make up for the missed dose, as this could increase the risk of side effects.

What are the special precautions before taking Pennsaid?

Before taking Pennsaid, here are several important precautions to keep in mind:

• Do not take Pennsaid if you are allergic to Diclofenac Sodium or any of the other ingredients in the medication.
• Pennsaid may increase the risk of serious cardiovascular events like heart attack or stroke, especially with long-term use or in individuals with pre-existing heart conditions.
• Avoid using Pennsaid immediately before or after undergoing heart bypass surgery (coronary artery bypass graft, or CABG).
• Avoid using Pennsaid if you have had severe allergic reactions to NSAIDs or aspirin.
• This medication should not be used during the last 20 weeks of pregnancy due to potential harm to the unborn baby, and breastfeeding while using Pennsaid is also not recommended.
• Do not apply Pennsaid to open wounds, irritated skin, or infected areas and protect the treated skin from sunlight.
• Make sure to inform your doctor if you have liver or kidney disease, high blood pressure, asthma, or fluid retention, as these conditions may require special monitoring.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Skin irritation at the treated area
• Gastrointestinal issues like indigestion or diarrhea
• Headache
• Stuffy nose or sore throat
• Increased blood pressure

Serious side effects may include:
• Rapid or irregular heartbeats
• Gastrointestinal bleeding
• Swelling of the face, lips, mouth, tongue, or throat
• Severe skin reactions like blistering or rash
• Yellowing of the skin or eyes (Jaundice)

This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Pennsaid (Diclofenac Sodium) may interact with other medications, so it's important to take caution before combining it with other drugs.

• NSAIDs
• Antidepressants
• Cyclosporine
• Lithium
• Methotrexate
• Blood thinners
• Heart or blood pressure medications

This list is not complete, always inform your doctor about all current and newly added medications to ensure safe usage and avoid potential drug interactions.

How should I store it?

Pennsaid should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F and 77°F). Keep it away from direct sunlight and out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Pennsaid (Diclofenac Sodium), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Symptoms of an overdose may include nausea, vomiting, stomach pain, dizziness, or even severe complications like gastrointestinal bleeding or kidney issues.

Is it safe for pregnant or breastfeeding women?

Pennsaid (Diclofenac Sodium) is generally not recommended for use during pregnancy or breastfeeding unless specifically directed by a doctor. This medication should not be used during the last 20 weeks of pregnancy due to potential harm to the unborn baby. While for breastfeeding women, it is unclear whether Pennsaid passes into breast milk. To avoid potential risks to the nursing infant, its use is typically not advised, and it's important to consult your doctor before using the medication to ensure safety.

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