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Pentasa (Mesalamine) is an anti-inflammatory medication prescribed to treat ulcerative colitis, proctitis, and proctosigmoiditis. It is also used to help prevent the recurrence of symptoms associated with ulcerative colitis.

This medication is used to treat ulcerative colitis, a type of bowel disease. It helps alleviate symptoms of ulcerative colitis, including diarrhea, rectal bleeding, and stomach pain. Mesalamine is part of a class of drugs called Aminosalicylates, and it works by reducing inflammation in the colon.

Take this medication by mouth with a glass of water, following the instructions on the prescription label. Take it at the same time each day. Do not cut, crush, or chew the capsules; swallow them whole.

If you miss a dose of Pentasa, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and take your next dose at the usual time. Do not take two doses at once to make up for the missed dose.

• Wheezing, shortness of breath, or difficulty breathing
• Swelling of the face, lips, or other parts of the body
• Hives on the skin, rash, or itching.
Before you start taking Pentasa, inform your doctor if you are allergic to any other medicines, foods, preservatives, or dyes. Also, let your doctor know if you have or have had any of the following medical conditions:
• An allergy to sulfasalazine, aspirin-like medications
• A bleeding disorder
• Kidney or liver problems
• History of asthma
Does it have any side effects?

Diarrhea, nausea, headache, or vomiting may occur. If any of these effects persist or worsen, contact your doctor or pharmacist promptly.

In rare cases, mesalamine can worsen ulcerative colitis. If your symptoms worsen after starting this medication (such as increased abdominal pain/cramping or bloody diarrhea), notify your doctor immediately.

Seek medical attention right away if you have any serious side effects, including persistent nausea/vomiting, signs of kidney issues (such as blood in urine, changes in urine output), dark urine, chest pain, severe stomach pain, yellowing of the skin or eyes, or shortness of breath.

A severe allergic reaction to this medication is rare, but seek immediate medical help if you notice any signs of a serious allergic reaction, such as swollen lymph nodes, fever, rash, itching/swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing.

Is it safe to take it with another drug?

Inform your doctor or pharmacist if you are taking any other medications, including those obtained without a prescription from your pharmacy, supermarket, or health food store. There is no available information on interactions between Pentasa and other medications. However, Mesalamine is part of a class of drugs called salicylates, which may interact with certain medications.

Medicines that may have an increased effect when used with Pentasa include:
• Anticoagulants, which are used to thin the blood or prevent blood clots such as Warfarin. When combined with Pentasa, these medications may have a stronger effect on thinning the blood.
• Glucocorticoids, which are used to treat inflammation, swelling, or allergies such as Prednisolon. When used with Pentasa, these medications may cause more pronounced side effects.
• Methotrexate, used to treat certain cancers and arthritis. When used with Pentasa, there may be an increased risk of toxic effects from the medication.
• Sulphonylureas, which are used to lower blood sugar and manage diabetes such as glibenclamide or glipizide. When taken with Pentasa, these medications may intensify the blood sugar-lowering effect.
Medicines that may have a reduced effect when used with Pentasa include:
• Probenecid or Sulfinpyrazone, which are used to treat gout or other conditions. When taken with Pentasa, these medications may become less effective.
• Spironolactone or Furosemide, which are used to increase urine production and lower blood pressure. When combined with Pentasa, their effectiveness may be reduced.
• Rifampicin, which is used to treat tuberculosis. When used with Pentasa, the effectiveness of this medication may be decreased.
Medicines that may increase the risk of reducing bone marrow activity when used with Pentasa include:
• Azathioprine, used to suppress the immune system
• Mercaptopurine, used to treat leukemia
If you're unsure about taking any of these medications, consult your doctor or pharmacist. They can provide more information on medicines to be cautious with or avoid while using Pentasa.
How should I store it?
Keep your Pentasa in its original packaging until you are ready to take your next dose. Store it in a cool, dry place with a temperature below 25°C, away from moisture, heat, and direct sunlight. Keep this medicine out of reach of children.
What action should I take in case of overdose?
If someone overdoses and shows severe symptoms like fainting or difficulty breathing, go to the nearest emergency department immediately.
Is it safe for pregnant or breastfeeding women?
Pentasa should only be used during pregnancy if prescribed by a doctor. This medication can pass into breast milk and may have harmful effects on a breastfeeding infant. It is important to consult your doctor before breastfeeding

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