Why is Prempro prescribed?

Prempro (Conjugated Estrogen + Medroxyprogesterone) is used to treat hot flashes (sudden strong feelings of heat) and vaginal changes and prevent osteoporosis (bone loss) commonly experienced by menopausal women.

What does it do?

Estrogen levels fall during menopause, hence producing menopausal symptoms like vaginal dryness and hot flashes. Prempro is a combination of two drugs, namely: conjugated estrogen which works as a replacement for estrogen normally produced in the body; and medroxyprogesterone, a form of progesterone, which regulates menstruation and ovulation.

How should I take it?

Prempro comes as a 1.5mg/0.3mg tablet taken whole, not crushed, with or without food. The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

Taking the dose properly at the scheduled time is needed to attain the desired effect of the drug. If you forgot to take your medicine, immediately take the next dose to make up for the missed dose. However, if it is near the time of the next dose, skip the missed dose and catch the next dose at the regular time. Never take two doses just to make up for your missed dose.

What are the special precautions before taking Prempro?

Avoid smoking and intake of grapefruit or grapefruit juice while taking this medication,

Inform your doctor about all the medications you are taking, your current and previous medical history, and any allergic reactions to Prempro or any other ingredients included in the manufacture of this medication.

Inform your doctor if you had any form of surgery or if you are planning to get one.

For the drug label information of Prempro, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Pain or tenderness felt on the breast
• Hair loss or unwanted hair growth
• Discoloration of the skin on the face
• Nausea, flatulence, abdominal pain
• Burning, itching, irritation, redness, or swelling of the vagina

Serious side effects include:
• Breast mass
• Abdominal pain, constipation
• Sudden severe headache
• Slurring of speech
• Yellow discoloration of the skin or eyes
• Blisters, hives, itching, or rash
• Swelling of any part of the face or limbs
• Hoarseness, difficulty breathing or swallowing
• Fatigue

Is it safe to take it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Prempro with any of the following medications:

• Actoplus
• Betamethasone dipropionate
• Biaxin
• Carfilzomib
• Coumadin
• Cardizem
• Dantrolene
• Diflucan
• Erythromycin
• Emend
• Glucophage
• Hemin
• Hytone
• Insulin
• Lenalidomide
• Lipitor
• Metaglip
• Nizoral
• Phenobarbital
• Promalidomide
• Pulmicort
• Rhinocort
• Sporanox
• Synthroid
• Thalidomide
• Tranexamic acid
• St. John’s wort

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Prempro in its original packaging in a clean environment away from excessive heat and moisture. Keep out of reach of children.

What action should I take in case of overdose?

Immediately call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Prempro is contraindicated in pregnant women or women trying to get pregnant. It can be excreted in human milk and is known to decrease the amount and quality of milk production. Hence, the potential risks and benefits of using Prempro in pregnant or breastfeeding infants should be carefully considered.

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