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Why is Prestalia prescribed?

Prestalia, a combination of perindopril (an ACE inhibitor) and amlodipine (a calcium channel blocker), is prescribed for the treatment of hypertension (high blood pressure). It is used in patients whose blood pressure is not adequately controlled on monotherapy or as an initial therapy for those likely to need multiple drugs to achieve their blood pressure goals.

What does it do?

Prestalia works by combining perindopril and amlodipine to lower blood pressure. Perindopril, an ACE inhibitor, inhibits an enzyme that constricts blood vessels, allowing them to relax and widen, which lowers blood pressure and enhances blood flow. While amlodipine, a calcium channel blocker, prevents calcium from entering heart and blood vessel muscle cells, promoting further relaxation and artery dilation.

How should I take it?

Prestalia should be taken once daily, preferably at the same time each day, with or without food. The recommended starting dose is one tablet containing 3.5 mg of perindopril and 2.5 mg of amlodipine, and adjustments can be made based on blood pressure goals. Your doctor may increase the dosage, with further adjustments after eight weeks if needed. The maximum daily dose is 14 mg of perindopril and 10 mg of amlodipine.

Additionally, various factors, such as body weight, medical conditions, and other medications, can affect dosing needs. Always follow your doctor’s specific recommendations and avoid altering your dosage without medical consultation.

What if I missed a dose?

If you miss a dose of Prestalia, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take double or extra doses to make up for the missed one.

What are the special precautions before taking Prestalia?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Before taking Prestalia (Viacoram), here are several important precautions to keep in mind:

• Do not take Prestalia if you are allergic to perindopril, amlodipine, or any ingredients of the medication.
• Do not use this medication if you have any of the following medical conditions:
• Currently taking aliskiren and have diabetes or moderate to severe kidney impairment.
• Currently using the combination medication sacubitril - valsartan.
• Undergoing certain blood treatments like dialysis or apheresis.
• Reduced kidney function.
• Experienced angioedema, including hereditary or idiopathic angioedema.
• Serious heart conditions affecting blood output.
• Hereditary lactose-related conditions.
• This medication should not be taken during pregnancy or breastfeeding unless deemed essential by a doctor. If you are pregnant or nursing, consult your healthcare provider before using this medication.
• Avoid combining this medication with aliskiren (especially in diabetic patients) and dantrolene, as these can lead to serious complications.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Diarrhea
• Headache
• Dizziness
• Rash
• Nausea
• Swelling of the legs and feet

Serious side effects may include:
• Difficulty breathing
• Fast or irregular heartbeat
• Severe headache
• Loss of coordination
• Yellowing of the skin or eyes (Jaundice)

This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Prestalia (Viacoram) can interact with various medications, so it's important to check for potential interactions before combining it with another drug. Some interactions may increase side effects, reduce effectiveness, or cause serious health risks.

Make sure to discuss with your doctor if you have taken or currently taking any of the following medications:

• Aliskiren
• Dantrolene
• NSAIDs such as ibuprofen or naproxen
• Potassium-sparing diuretics or supplements
• Lithium
• Other blood pressure medications

This is not a complete list of all the potential drug interactions, always consult your doctor or pharmacist before combining Prestalia with other medications to ensure safety.

How should I store it?

Prestalia should be stored in its original container at room temperature, ideally between 15°C and 30°C (59°F and 86°F). Keep it away from direct sunlight and out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Prestalia, it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Symptoms of overdose may include severe dizziness, fainting, or a significant drop in blood pressure.

Is it safe for pregnant or breastfeeding women?

Prestalia (Viacoram) is not recommended for use during pregnancy and breastfeeding. ACE inhibitors like perindopril can cause harm to the developing fetus, especially in the second and third trimesters, leading to serious complications and developmental problems. If pregnancy is detected, Prestalia should be discontinued immediately.

Amlodipine and Perindopril can both pass into breast milk, though their effects on infants are not well established. Consult your healthcare provider before using these medications while breastfeeding.

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