NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Prezista prescribed?

Prezista (Darunavir) is prescribed as an antiviral medication used to treat HIV-1 infection in adults and children 3 years of age and older. It belongs to the protease inhibitor class of drugs, which work by preventing the virus from multiplying in the body. Prezista is not a cure for HIV or AIDS, but it helps manage the infection when taken in combination with ritonavir and other antiretroviral medications.

What does it do?

Prezista (Darunavir) works by blocking the action of HIV protease, an enzyme that the virus needs to replicate. By inhibiting this enzyme, Prezista prevents the virus from producing mature infectious particles, thereby reducing the amount of HIV in the body and helping the immune system function more effectively.

How should I take it?

Prezista should be taken with food to ensure proper absorption, and it’s important to take it consistently to maintain viral suppression. The medication must be co-administered with ritonavir, which boosts its effectiveness.

• For treatment-naive adults, the recommended dose of Prezista is 800 mg, taken with 100 mg of ritonavir once daily with food.
• For treatment-experienced adults, the recommended dose of Prezista is 600 mg, taken with 100 mg of ritonavir twice daily with food.
• For pediatric patients (ages 3 and older), the recommended dose is based on body weight and should not exceed the recommended dose for adults.
• For pregnant patients, the recommended dose of Prezista is 600 mg with ritonavir 100 mg twice daily with food.

What if I missed a dose?

If you miss a dose of Prezista, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take double or extra doses to make up for the missed one.

What are the special precautions before taking Prezista?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Before taking Prezista, here are several precautions to keep in mind:

• Avoid Prezista if you have severe liver disease, as it can cause serious liver problems.
• To make sure Prezista is safe for you, disclose all your medical conditions with your doctor, particularly if you have:
• Diabetes
• A bleeding disorder such as hemophilia
• An allergy to sulfa drugs
• Liver disease (especially hepatitis B or C)
• Prezista can make hormonal birth control less effective. Use barrier methods like condoms, diaphragms, cervical caps, or contraceptive sponges as alternatives.
• To reduce the risk of HIV transmission to a newborn, follow your prescribed medications consistently throughout pregnancy to manage the infection effectively.
• Prezista and ritonavir should not be administered to children under 3 years of age or those weighing less than 22 pounds (10 kilograms).
Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Diarrhea
• Nausea
• Rash
• Heartburn
• Stomach discomfort
Serious side effects may include:
• High blood sugar (Hyperglycemia)
• Severe skin rash
• Liver problems such as hepatitis
• Swelling of the face, lips, tongue, or throat)
• Yellowing of the skin or eyes (Jaundice)
This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.
Is it safe to take it with another drug?

Prezista (Darunavir) may interact with certain medications, and some drugs should not be taken together. To ensure safety, always check for potential interactions before combining it with other treatments.

Some drugs should not be taken or combined with Prezista, including:

• Certain heart medications)
• Cholesterol-lowering drugs)
• St. John's wort (herbal supplement))
• Rifampin (antibiotic))
• Ergot medicines
• Certain sedatives
This is not a complete list of all the potential drug interactions, always consult your doctor or pharmacist before combining Prezista with other medications to ensure safety.
How should I store it?
Prezista should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F and 77°F).
What are the special precautions before taking Prezista?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Before taking Prezista, here are several precautions to keep in mind:

• Avoid Prezista if you have severe liver disease, as it can cause serious liver problems.
• To make sure Prezista is safe for you, disclose all your medical conditions with your doctor, particularly if you have:
• Diabetes
• A bleeding disorder such as hemophilia
• An allergy to sulfa drugs
• Liver disease (especially hepatitis B or C)
• Prezista can make hormonal birth control less effective. Use barrier methods like condoms, diaphragms, cervical caps, or contraceptive sponges as alternatives.
• To reduce the risk of HIV transmission to a newborn, follow your prescribed medications consistently throughout pregnancy to manage the infection effectively.
• Prezista and ritonavir should not be administered to children under 3 years of age or those weighing less than 22 pounds (10 kilograms).
Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Diarrhea
• Nausea
• Rash
• Heartburn
• Stomach discomfort
Serious side effects may include:
• High blood sugar (Hyperglycemia)
• Severe skin rash
• Liver problems such as hepatitis
• Swelling of the face, lips, tongue, or throat)
• Yellowing of the skin or eyes (Jaundice)
This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.
Is it safe to take it with another drug?
Prezista (Darunavir) may interact with certain medications, and some drugs should not be taken together. To ensure safety, always check for potential interactions before combining it with other treatments. Some drugs should not be taken or combined with Prezista, including:
• Cholesterol-lowering drugs
• St. John's wort (herbal supplement)
• Rifampin (antibiotic)
• Ergot medicines
• Certain sedatives
This is not a complete list of all the potential drug interactions, always consult your doctor or pharmacist before combining Prezista with other medications to ensure safety.
How should I store it?
Prezista should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F and 77°F).
What action should I take in case of overdose?
If you suspect an overdose of Prezista (Darunavir), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Symptoms of an overdose may include severe nausea, vomiting, dizziness, and liver complications.
Is it safe for pregnant or breastfeeding women?

Prezista can be used during pregnancy, but the recommended dose is 600 mg of Prezista with 100 mg of ritonavir twice daily with food. It is important for pregnant individuals to continue their HIV treatment to prevent transmission to the baby.

However, breastfeeding is not recommended for women with HIV, as the virus can be transmitted through breast milk. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider to ensure the safest treatment plan.

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