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Why is Probenecid prescribed?

Probenecid is prescribed to treat gout and gouty arthritis by lowering uric acid levels in the body, helping to prevent painful flare-ups. Additionally, Probenecid is sometimes used alongside penicillin antibiotics to enhance their effectiveness by preventing their rapid elimination from the body. This allows the antibiotics to remain in the bloodstream longer, improving their ability to fight infections.

What does it do?

Probenecid works by blocking the reabsorption of uric acid in the kidneys, increasing its excretion through urine. This helps lower uric acid levels in the blood, preventing the formation of painful crystals in joints, which cause gout attacks.

How should I take it?

Probenecid is typically taken by mouth with a full glass of water. It is usually prescribed twice a day for gout treatment and four times a day when used with antibiotics to enhance their effectiveness. Follow your doctor's instructions carefully and do not take more or less than prescribed. For better consistency, try taking it at the same times each day to help you remember your doses.

What are the special precautions before taking Probenecid?

Before taking Probenecid, here are several important precautions to keep in mind:

• Avoid using Probenecid if you are allergic to it, have uric acid kidney stones, are experiencing an active gout attack, or have a blood cell disorder such as anemia or low white blood cell count.
• Disclose all your medical conditions to your doctor, particularly if you have:
• Blood disorders
• Kidney stones
• Ulcers
• Kidney disease
• Do not give this medication to others, even if they have similar condition, as it may pose health risks.
• The safety of this medication during pregnancy and breastfeeding remains uncertain. If you are pregnant or nursing, consult your doctor for guidance before taking it.
• Probenecid may increase the risk of uric acid kidney stones when first taken, so it’s essential to follow your healthcare provider’s guidance on avoiding certain beverages and foods that could contribute to this risk.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Headache
• Dizziness
• Nausea and vomiting
• Loss of appetite
• Sore gums

Serious side effects may include:
• Difficulty breathing
• Severe gout flares
• Painful or difficult urination
• Swelling of the face, lips, mouth, tongue, or throat
• Yellowing of the skin or eyes (Jaundice)

This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Probenecid can interact with various medications, so it's important to check for potential interactions before taking it with another drug. Tell your healthcare provider about all prescription and over the counter (OTC) medicines, vitamins, minerals, herbal products, and supplements you are currently taking.

Before taking Probenecid, consult your doctor if you are using any of the following medications:

• Aspirin & NSAIDs (nonsteroidal anti-inflammatory drugs)
• Antibiotics such as penicillin or ampicillin
• Kidney-related medications
• Diabetes medications
• Methotrexate

This is not a complete list of all the potential drug interactions, always consult your doctor or pharmacist before combining Probenecid with other medications to ensure safety.

How should I store it?

Probenecid should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F and 77°F). Keep it away from direct sunlight and ensure it remains out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Probenecid, it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital.

Is it safe for pregnant or breastfeeding women?

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider to determine whether Probenecid is suitable for you. This medication should only be used during pregnancy if necessary, so discuss its potential risks and benefits with your doctor. Additionally, it is uncertain whether the drug passes into breast milk, seek medical advice before breastfeeding.

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