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Why is Proloprim prescribed?

Proloprim (Trimethoprim) is frequently used to treat bladder infections, but its effectiveness may vary depending on the specific bacteria causing the infection. In some cases, bacteria in certain areas may have developed resistance to Proloprim, reducing its effectiveness.

What does it do?

Proloprim is an antibiotic classified as an antifolate. It works by inhibiting bacteria from producing folic acid, a substance essential for their growth and survival.

How should I take it?

You can take Proloprim with or without food. If you experience an upset stomach, taking it with food may help alleviate this side effect.

Take Proloprim exactly as directed. Be sure to complete the full course of treatment, even if you start feeling better. Stopping the medication too soon can cause the infection to return and may make it more difficult to treat.

What if I missed a dose?

If you miss a dose of this medicine, take it as soon as you remember. But, if it's nearly time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double dose.

What are the special precautions before taking Proloprim?

The presence of other medical conditions may impact the use of this medication. Be sure to inform your doctor if you have any other health issues, particularly:

• Anemia: Individuals with anemia may have a higher risk of blood-related side effects.
• Kidney disease: Those with kidney disease may be more likely to experience side effects.
• Liver disease: Patients with liver disease may have an increased risk of side effects.

If you will be taking this medicine for an extended period, it's important for your doctor to monitor your progress during regular check-ups. This allows your doctor to identify any potential side effects caused by the medication.

If your symptoms do not improve within a few days, or if they worsen, contact your doctor. If this medicine causes anemia, your doctor may recommend taking folic acid (a vitamin) daily to help treat the condition. If prescribed, it is important to take folic acid every day alongside this medication and not miss any doses.

Proloprim can cause blood-related issues, which may increase the risk of infections, slow healing, and gum bleeding. For this reason, you should be cautious when using regular toothbrushes, dental floss, or toothpicks. Delaying dental work until your blood counts return to normal may be necessary. If you have concerns about oral hygiene during treatment, consult your doctor or dentist.

Some individuals taking Proloprim may become more sensitive to sunlight. Even brief exposure can lead to severe skin rashes, redness, itching, sunburn, or discoloration. To protect yourself:

• Avoid direct sunlight, especially between 10:00 a.m. and 3:00 p.m., if possible.
• Do not use tanning beds, sunlamps, or tanning booths.
• Use a sunscreen with an SPF of at least 15. Some people, particularly those with fair skin, may need a higher SPF. If you're unsure, consult your doctor.
• If you experience a severe reaction to sunlight, contact your doctor.
Does it have any side effects?
These side effects may improve as your body adjusts to the medication. However, if they persist or worsen, be sure to inform your healthcare provider right away.
Common side effects may include:
• Stomach pain
• Diarrhea
• Rash
• Itching
• Nausea
• Vomiting
• Increased sensitivity to sunlight
Serious side effects may include: Seek immediate medical attention if you have any of the following:
• Allergic reactions-blisters, hives, rash, difficulty breathing, or swelling of the mouth or face.
• Infectious diarrhea (C. difficile-related): foul-smelling diarrhea, nausea, fever, and frequent bowel movements (up to 15 times a day).
Other side effects not mentioned may also occur in some individuals. If you notice any additional symptoms, consult your physician.
Is it safe to take it with another drug?

While some medications should never be used together, in certain cases, two different medicines may be combined even if an interaction is possible. In such situations, your doctor may adjust the dosage or take additional precautions. It's crucial that your doctor knows if you're taking any of the medications listed below.

It is not recommended to use this medicine with the following medications. Your doctor may choose not to prescribe this medication or may adjust the other medications you're taking:
• Dofetilide
• Levomethadyl
Using this medicine with any of the following medications is generally not recommended, but may be necessary in certain situations. If both medications are prescribed together, your doctor may adjust the dosage or frequency of one or both medicines
• Azilsartan
• Azimilide
• Benazepril
• Bretylium
• Captopril
• Chloroquine
• Clarithromycin
• Digoxin
• Droperidol
• Eprosartan
• Erythromycin
• Fluconazole
• Fluoxetine
• Halothane
• Hydroquinidine
• Irbesartan
• Isradipine
• Lorcainide
• Losartan
• Methotrexate
• Valsartan
• Zofenopril

Ask your doctor or pharmacist for other possible interactions not listed within this section.

Taking this medicine with any of the following medications may increase the risk of certain side effects, but using both drugs may still be the most appropriate treatment for you. If both medications are prescribed together, your doctor may adjust the dosage or frequency of one or both drugs:
• Amantadine
• Anisindione
• Didanosine
• Repaglinide
• Rosiglitazone
• Tolbutamide
Using this medicine with alcohol is generally not recommended, but may be necessary in some situations. If both are used together, your doctor may adjust the dosage or frequency of the medication, or provide specific instructions regarding the use of alcohol, food, or tobacco.
How should I store it?
Store the medicine in a tightly closed container at room temperature, away from heat, moisture, and direct sunlight. Do not allow it to freeze. Keep out of reach of children.
What action should I take in case of overdose?
If you or someone else has taken too much Proloprim, seek immediate medical attention or go to the nearest emergency department right away.
Is it safe for pregnant or breastfeeding women?
Be sure to inform your doctor if you are pregnant or breastfeeding before using Proloprim. Research indicates that the antibiotic may harm babies during early pregnancy or while breastfeeding. Proloprim should only be used during pregnancy or breastfeeding if absolutely necessary.

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