Why is Questran prescribed?

Cholestyramine (Questran) is prescribed to lessen the amount of cholesterol in the blood, particularly low-density lipoprotein (LDL) cholesterol. It is used in combination with dietary modifications when diet alone is not able to lower blood cholesterol levels.

What does it do?

Increased levels of cholesterol in the blood can result in the narrowing of your arteries due to the deposition of fats. This can affect the circulation of blood and oxygen to different organs of your body and may make you more prone in developing heart attacks, strokes, and heart diseases.

Questran belongs to a drug class called bile acid sequestrants and it works by combining with bile acids (containing cholesterol) in the intestine, forming a complex which are to be excreted in feces. This prevents cholesterol to be absorbed, allowing a decrease in cholesterol levels in the blood.

How should I take it?

Questran and its generic equivalents are currently available as a powder in 4g packets. The contents of the packet should be taken by mouth and mixed with liquids (such as water, milk, or fruit juices with pulp) or foods (such as soup, crushed pineapple, or applesauce).

If you need to take other medications, take them 1 hour before or 4 hours after taking Questran to prevent interactions.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before using Questran?

Inform your doctor about all the medications you are taking, your current and previous medical history, and any allergic reactions to Questran or any other ingredients included in the manufacture of this medication.

Inform your doctor if you had any form of surgery or if you are planning to get one.

For the drug label information of Questran, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Bloating
• Diarrhea
• Flatulence
• Heartburn
• Irritation of the tongue
• Loss of appetite
• Mild constipation
• Nausea
• Stomach pain
• Vomiting

Serious side effects include:
• Black tarry stools
• Bloody urine
• Bruising or bleeding
• Constipation that is ongoing or getting worse
• Severe stomach pain

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Questran with any of the following medications:

• Aristocort
• Benzthiazide
• Bumetanide
• Calcort
• Chlorpropamide
• Chlorthalidone
• Coumadin
• Demadex
• Dexamethasone
• Diethylstilbestrol
• Drisdol
• Evista
• Flagyl
• Folic acid
• Hytone
• Inderal
• Lanoxin
• Lasix
• Lescol
• Liotrix
• Lipitor
• Lofibra
• Lomitapide
• Loperamide
• Lopid
• Lozol
• Metolazone
• Mevacor
• Mycophenolate mofetil
• Mycophenolic acid
• Phenobarbital
• Phenylbutazone
• Pravachol
• Prednisone
• Rhinocort
• Rocaltrol
• Synthroid
• Teriflunomide
• Tindamax
• Tolbutamide
• Troglitazone
• Valproic acid
• Vancocin
• Yasmin
• Zetia

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Questran in a tight container in a clean environment away from excessive heat and moisture.

What action should I take in case of overdose?

Call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Present data suggest that the use of Questran in pregnant women has not established its developmental risks.

There is also limited data on the presence of Questran in human milk or its effects on the breastfed infant. Hence, the potential risks and benefits of using Questran in pregnant or breastfeeding women should be carefully considered.

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