Why is Rapamune prescribed?

Rapamune (Sirolimus) is a prescription medication used to prevent organ rejection in individuals aged 13 and older who have undergone a kidney transplant. Rejection occurs when the body's immune system identifies the transplanted organ as a foreign threat and tries to attack it. Rapamune is typically used in combination with other medications, such as cyclosporine (Gengraf, Sandimmune, Neoral), and corticosteroids.

What does it do?

Rapamune works by suppressing the body's immune system, helping it accept the transplanted organ as though it were its own. Additionally, sirolimus may be used to treat a specific lung condition called Lymphangioleiomyomatosis (LAM).

How should I take it?

Take this medication by mouth as prescribed by your doctor, typically once a day. Swallow the tablets whole; do not crush, chew, or break them. If you experience nausea or an upset stomach, you can take the medication with food. The dosage will depend on your weight, medical condition, lab results, and how you respond to the treatment.

What if I missed a dose?

If you miss a dose of Rapamune, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and take your next dose at the usual time. Do not double dose.

What are the special precautions before taking Rapamune?

You should not use Rapamune if you have ever had a lung or liver transplant.

Rapamune may cause an overproduction of white blood cells, which can increase the risk of cancer, severe brain infections that may lead to disability or death, or viral infections that could cause kidney transplant failure. Contact your doctor immediately if you experience any of the following: fever, flu-like symptoms, pain or burning during urination, new skin lesions, changes in mental state, vision problems, weakness on one side of the body, difficulty speaking or walking, or pain around your transplant.

Before using Rapamune, do not take it if you are allergic to sirolimus, or if you have previously had a lung or liver transplant. Discuss the risks and benefits of using this medication with your doctor.

Rapamune can affect your immune system and may cause an overproduction of certain white blood cells, potentially leading to cancer, severe brain infections, or viral infections that could harm a kidney transplant. To ensure Rapamune is safe for you, inform your doctor if you have a history of:

• High cholesterol or triglycerides
• Liver disease
• Cytomegalovirus (CMV)
• A family history of Melanoma
While taking Rapamune, avoid the following:
• Avoid direct sunlight or tanning beds, as Rapamune may increase your risk of skin cancer. Always wear protective clothing and use sunscreen with an SPF of 30 or higher when outdoors.
• Stay away from people who are sick or have infections. Contact your doctor immediately if you notice signs of infection.
• Do not let Rapamune oral liquid come into contact with your skin. If it does, wash the affected area with soap and water. If the medication gets into your eyes, rinse them with plain water.
• Grapefruit can interact with sirolimus and cause unwanted side effects. Avoid consuming grapefruit or grapefruit juice while taking Rapamune.
• Do not receive any "live" vaccines while on Rapamune.
Does it have any side effects?
Most side effects are mild and go away as your body adjusts to the medication. However, if they persist or if you're concerned about them, consult your doctor.
Common side effects may include:
• Abdominal pain
• Anemia (low red blood cell count)
• Edema (swelling)
• Nausea
• Increased blood lipid levels
• Low blood platelet count
• Headache
• Fever
• Urinary tract infection
• Diarrhea
• High blood pressure
• Joint pain
Serious side effects may include:
• Redness, slow healing of a wound
• Unexplained bruising or bleeding
• A new skin lesion or a mole that has changed in size or color
• Sudden chest pain or discomfort, or difficulty breathing
• Tenderness around the transplanted kidney
• Signs of infection, such as fever, chills, skin sores, painful mouth sores, flu symptoms, or burning during urination
• Symptoms of low red blood cells (anemia), such as unusual fatigue, pale skin, dizziness, cold hands and feet or shortness of breath.
This is not a full list of side effects, and others may occur. Contact your doctor for advice if you experience any side effects.
Is it safe to take it with another drug?
Inform your doctor about all the medications you are currently taking. Many drugs can interact with Rapamune, including:
• Antibiotics or antifungal medications
• Antiviral medications for HIV or hepatitis C
• Cycloset
• Cyclosporine
• Danazol
• St. John's wort
• Tacrolimus
• Cholesterol-lowering medications
• Heart or blood pressure medications
• Medications to reduce stomach acid or treat ulcers
This is not a complete list, and other medications may also interact with sirolimus consult with your doctor or pharmacist.
How should I store it?
Store at or below 25°C. Keep the blister pack in the outer carton to protect it from light. Keep this medication out of the reach and sight of children.
What action should I take in case of overdose?
If someone overdoses and exhibits severe symptoms such as fainting or difficulty breathing, contact your nearest emergency department immediately.
Is it safe for pregnant or breastfeeding women?
Rapamune may not be safe to use during pregnancy. Your doctor will assess the potential benefits and risks before prescribing it. While it is likely unsafe to use while breastfeeding, as it may pass into breast milk and harm the baby. Be sure to consult your doctor before taking this medication.

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