Why is Retrovir prescribed?

Zidovudine (Retrovir) is prescribed in combination with other medications for the treatment of human immunodeficiency virus (HIV) infection. It is also prescribed to prevent the transmission of human immunodeficiency virus from a pregnant woman, who is HIV-positive, to her baby.

What does it do?

The human immunodeficiency virus attacks the white blood cells in the body, which are responsible for fighting off infections, causing you to be more prone to getting severe infections such as acquired immunodeficiency syndrome (AIDS) or HIV-related diseases. Zidovudine is classified as a nucleoside reverse transcriptase inhibitor that primarily works by inhibiting an enzyme needed by the virus to replicate, eventually stopping the spread of the virus.

How should I take it?

Retrovir and its generic equivalents are currently available as 100mg capsules. Each capsule should be taken as a whole (do not split) by mouth with or without food.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only use this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Retrovir?

Before taking Zidovudine, tell your doctor or pharmacist if you have any allergies to food or to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

Inform your doctor about your past and current medical history especially if you have or have had kidney disease, muscle problems, anemia, or bone marrow suppression.

Taking Zidovudine can strengthen your immune system and you may be able to fight off any existing infections or conditions you may have. Symptoms of these infections or conditions may appear and develop. Inform your doctor if you notice your symptoms are becoming worse.

For the drug label information of Retrovir, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Appetite loss
• Cough
• Fever
• Headache
• Loss of body fat
• Nausea
• Vomiting

Serious side effects include:
• Balance problems
• Chills
• Cold sores
• Dark urine
• Diarrhea
• Difficulty speaking or swallowing
• Night sweats
• Shortness of breath
• Stomach pain
• Unusual bleeding
• Weight loss
• Yellowing of the skin or eyes

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Retrovir with any of the following medications:

• Adalimumab
• Anakinra
• Arava
• Baricitinib
• Bexarotene
• Cataflam
• Certolizumab
• Cladribine
• Clozapine
• Cytarabine
• Deferiprone
• Doxorubicin
• Etanercept
• Etoposide
• Fingolimod
• Ganciclovir
• Golimumab
• Infliximab
• Ketorolac
• Lipitor
• Lofibra
• Lomitapide
• Mipomersen
• Natalizumab
• Ozanimod
• Pexidartinib
• Rheumatrex
• Ribavirin
• Siponimod
• Stavudine
• Teriflunomide
• Tofacitinib
• Valganciclovir

If you are using any prescription, non-prescription, and herbal medications, inform your doctor and pharmacist for proper information and ask for other possible interactions not listed within this section.

How should I store it?

Store Retrovir at room temperature (25 °C) in a clean environment away from light and moisture, as well as children and pets. Do not refrigerate. Do not remove the desiccant in the original container. Throw away if unused or expired. Do not flush in the toilet. Consult the pharmacist for proper disposal.

What action should I take in case of overdose?

Call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Zidovudine to determine drug-associated risks of major maternal defects, miscarriages, and fetal outcomes.

Limited data have been established indicating the presence of Zidovudine in human milk. Consult your doctor first before breastfeeding.

The use of Zidovudine in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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