Why is Rinvoq prescribed?

Upadacitinib (Rinvoq) is prescribed alone or in combination with other medications for the treatment of rheumatoid arthritis. It is prescribed to patients who have previously been on treatment with methotrexate but did not respond well to it or were not able to tolerate it.

What does it do?

Rheumatoid arthritis is an autoimmune disorder (a condition where your immune system targets and attacks your own body) affecting the joint linings, causing pain, stiffness, and swelling in the affected joints. It usually starts affecting smaller joints (such as joints in the hands and feet) and spreads to larger joints (such as joints in the elbows and knees) as the disease advances. Upadacitinib is classified as a Janus kinase inhibitor that works by inhibiting processes in the body that contributes to the occurrence of symptoms in rheumatoid arthritis.

How should I take it?

Rinvoq and its generic equivalents are currently available as 15mg extended-release tablets. Each tablet should be taken as a whole (do not split) by mouth with or without food.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only use this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Rinvoq?

Before taking Upadacitinib, tell your doctor or pharmacist if you have any allergies to food or to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

Inform your doctor about your past and current medical history especially if you have or have had liver disease, kidney disease, hepatitis, stomach problems, intestinal problems, blood clots, cancer, shingles, high cholesterol levels, lung disease, diabetes, a chronic infection, or a weak immune system.

Consult your doctor before if you are scheduled to have any vaccinations or if you have been vaccinated recently.

For the drug label information of Rinvoq, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Cough
• Fever
• Nausea
• Runny nose
• Sneezing
• Sore throat

Serious side effects include:
• Change in bowel movements
• Chest pain
• Chills
• Coughing up blood
• Diarrhea
• Fatigue
• Muscle pain
• Night sweats
• Skin rashes
• Stomach pain
• Weight loss

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Rinvoq with any of the following medications:

• Abatacept
• Amprenavir
• Azathioprine
• Beclomethasone
• Biaxin
• Bleomycin
• Carboplatin
• Cytarabine
• Dacarbazine
• Delavirdine
• Dilantin
• Docetaxel
• Epirubicin
• Etoposide
• Floxuridine
• Fludarabine
• Gemcitabine
• Hydroxyurea
• Idarubicin
• Ifosfamide
• Infliximab
• Linezolid
• Lomustine
• Nelarabine
• Niraparib
• Nizoral
• Olaparib
• Ozanimod
• Prednisone
• Primaquine
• Prograf
• Purinethol
• Retrovir
• Rheumatrex
• Rituximab
• Streptozocin
• Tegretol
• Telaprevir
• Teniposide
• Trimetrexate
• Vinorelbine

If you are using any prescription, non-prescription, and herbal medications, inform your doctor and pharmacist for proper information and ask for other possible interactions not listed within this section.

How should I store it?

Store Rinvoq at room temperature (25 °C) in a clean environment away from light and moisture, as well as children and pets. Do not refrigerate. Do not remove the desiccant in the original container. Throw away if unused or expired. Do not flush in the toilet. Consult the pharmacist for proper disposal.

What action should I take in case of overdose?

Call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Upadacitinib to determine drug-associated risks of major maternal defects, miscarriages, and fetal outcomes.

Limited data have been established indicating the presence of Upadacitinib in human milk. Consult your doctor first before breastfeeding.

The use of Upadacitinib in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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