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Why is Ruzurgi prescribed?

Ruzurgi (Amifampridine) is prescribed for the treatment of Lambert-Eaton myasthenic syndrome (LEMS) in patients aged 6 to less than 17 years. Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder that affects the neuromuscular junction, leading to muscle weakness.

What does it do?

Ruzurgi (Amifampridine) is a potassium channel blocker that helps improve muscle function in people with Lambert-Eaton myasthenic syndrome (LEMS). It works by blocking potassium channels in nerve cells, which allows more calcium to enter. This increase in calcium helps release acetylcholine, a neurotransmitter that improves communication between nerves and muscles, leading to stronger muscle contractions.

How should I take it?

Ruzurgi should be taken with or without food, as directed by your doctor. The tablet can be broken in half if needed. If swallowing tablets is difficult, a liquid suspension can be prepared. The standard dose depends on age and weight:.

• Patients 6 to less than 17 years of age weighing equal to or more than 45 kg: Start with 15-30 mg daily, divided into multiple doses. Increase by 5-10 mg increments as needed, up to 100 mg per day.
• Patients 6 to less than 17 years weighing less than 45 kg: Start with 7.5-15 mg daily, divided into multiple doses. Increase by 2.5-5 mg increments, up to 50 mg per day.

What if I missed a dose?

If you miss a dose of Ruzurgi, take it as soon as you remember. If your next dose is approaching, skip the missed one and continue following your usual schedule. Avoid taking extra or double doses to compensate for the missed dose.

What are the special precautions before taking Ruzurgi?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Before taking Ruzurgi, here are several important precautions to keep in mind:

• Avoid taking Ruzurgi if you have a known allergy to Amifampridine or any of its components to prevent adverse reactions.
• Ruzurgi may increase the risk of seizures, especially in patients with a history of seizures.
• Avoid combining Ruzurgi with medications that lower seizure threshold or cholinergic drugs, as they may increase side effects.
• Avoid sharing this medication with others, even if they have a similar condition, as it may cause unexpected health risks or adverse effects.
• Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the effects on the baby are not fully known.
• Ruzurgi is approved for children aged 6 to less than 17 years, but safety in younger children and elderly patients is not well established.
• Patients with renal or hepatic impairment should start with the lowest recommended dose and be monitored closely.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Abdominal pain or indigestion
• Numbness or tingling sensations
• Dizziness
• Nausea
• Muscle spasms

Serious side effects may include:
• Difficulty breathing
• Seizures
• Swelling of the face, lips, tongue, or throat
• Severe dizziness or fainting

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Ruzurgi (Amifampridine) can interact with various medications, so it's important to check for potential interactions before taking it with another drug. Combining Ruzurgi with other medications may reduce their effectiveness or cause adverse effects.

Before taking Ruzurgi, consult your doctor if you are using any of the following medications:

• Antidepressants
• Antipsychotics
• Cholinergic drugs
• Beta-blockers and calcium channel blockers
• Certain antibiotics

This is not a complete list of all the potential drug interactions, always consult your doctor or pharmacist before combining Ruzurgi with other medications to ensure safety.

How should I store it?

Ruzurgi should be stored in its original container at room temperature, ideally between 68°F and 77°F (20°C and 25°C). Keep it away from direct sunlight and out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Ruzurgi (Amifampridine), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Overdose symptoms may include seizures, irregular heartbeat, severe dizziness, or difficulty breathing.

Is it safe for pregnant or breastfeeding women?

The safety of Ruzurgi (Amifampridine) for pregnant or breastfeeding women is not well established. There is limited data on its effects during pregnancy, and it is unknown whether it passes into breast milk. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider for guidance on its use to ensure safety for both you and your baby.

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