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Why is Selzentry prescribed?

Selzentry (Maraviroc) is prescribed as an antiviral medication used in combination with other drugs to treat CCR5-tropic HIV-1, a strain of HIV that can lead to acquired immunodeficiency syndrome (AIDS). Selzentry is not a cure for HIV or AIDS but helps manage the virus and slow its progression. It is prescribed for adults and children who weigh at least 4.4 pounds (2 kilograms).

What does it do?

Selzentry (Maraviroc) works as a CCR5 antagonist, meaning it blocks the CCR5 receptor on immune cells. This receptor is one of the key entry points that HIV uses to infect cells. By preventing HIV from binding to CCR5, Selzentry stops the virus from entering and replicating inside immune cells, helping to slow the progression of HIV (CCR5-tropic) infection.

How should I take it?

Selzentry should be taken exactly as prescribed by your doctor. Selzentry tablets and oral solution are taken by mouth twice daily and can be administered with or without food. This medication must be used in combination with other antiretroviral drugs, and its recommended dosage may vary depending on concomitant medications due to potential drug interactions.

What if I missed a dose?

If you miss a dose of Selzentry, take it as soon as you remember. If your next dose is approaching, skip the missed one and continue following your usual schedule. Avoid taking extra or double doses to compensate for the missed dose.

To maintain the effectiveness of your HIV treatment, try to take Selzentry at the same time every day. If you frequently miss doses, consider setting reminders or discussing alternative strategies with your healthcare provider.

What are the special precautions before taking Selzentry?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Before taking Selzentry, here are several important precautions to keep in mind:

• Avoid taking Selzentry if you're allergic to Maraviroc, or any of the ingredients in the medication.
• Disclose all your current or past medical conditions to your doctor, particularly if you have:
• Kidney disease
• Liver disease (hepatitis B or C)
• Heart disease
• Low blood pressure
• Selzentry is not recommended for patients with severe renal impairment who are taking potent CYP3A inhibitors or inducers.
• Avoid sharing this medication with others, even if they have a similar condition, as it may cause unexpected health risks or adverse effects.
• If you are pregnant, considering pregnancy, or breastfeeding, consult your doctor to understand the potential risks and benefits of taking this medication.
• Selzentry may impact your alertness and coordination, so avoid driving or engaging in tasks that require full attention until you understand how the medication affects you.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Dizziness or lightheadedness
• Cough
• Fever
• Stomach pain
• Diarrhea

Serious side effects may include:
• Chest pain or irregular heartbeat
• Severe rash or allergic reactions
• Swelling of the face, lips, mouth, tongue, or throat
• Severe headache
• Yellowing of skin or eyes (jaundice)

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Selzentry (Maraviroc) can interact with various medications, so it's important to check for potential interactions before taking it with another drug. Some interactions may increase side effects or reduce effectiveness. Before taking Selzentry, consult your doctor if you are using any of the following medications:

• Clarithromycin
• Heart & Blood Pressure Medications
• St. John’s wort
• Ritonavir
• Nefazodone
• Other HIV or AIDS Medications

This is not a complete list of all the potential drug interactions, always consult your doctor or pharmacist before combining Selzentry with other medications to ensure safety.

How should I store it?

Selzentry should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

What action should I take in case of overdose?

If you suspect an overdose of Selzentry (Maraviroc), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Overdose symptoms may include severe dizziness, fainting, or dangerously low blood pressure.

Is it safe for pregnant or breastfeeding women?

Selzentry should only be used during pregnancy if the benefits outweigh the risks. For breastfeeding, it is not recommended because maraviroc can be excreted into breast milk, and there is a risk of HIV transmission to the infant. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider for guidance on its use to ensure safety for both you and your baby.

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