Why is Silenor prescribed?

Silenor (Doxepin) is a tricyclic antidepressant prescribed to help adults with insomnia (difficulty sleeping) stay asleep.

What does it do?

Silenor belongs to a group of medicines called tricyclic antidepressants (TCAs). It may work by increasing the amount of natural chemicals called norepinephrine and serotonin in the brain. Silenor tablets may work by affecting a substance in the body called histamine to achieve its sleep-inducing effects.

How should I take it?

Take Silenor (Doxepin) 30 minutes before bedtime. Only take it if you can get a full night's sleep, as taking it without enough sleep may leave you feeling drowsy the next day. Also, note avoid taking Silenor (Doxepin) within 3 hours of eating as food can delay the onset of the medication's effects and don't mix Silenor with alcohol since it will cause you too to become sleepy.

What if I missed a dose?

Take Silenor as soon as you remember. Do not take two doses at once and avoid taking Silenor if you won't have enough time for a full night's sleep before you need to be active again.

What are the special precautions before taking Silenor?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Allergies to Ingredients: Individuals who are allergic to any of the following should avoid using Silenor.

Glaucoma: Silenor may increase eye pressure and could trigger or worsen narrow-angle glaucoma, which may lead to blindness.

Urinary Retention: Silenor may make it difficult to empty your bladder, especially if you already have a blockage or take other medications for an overactive bladder.

Photosensitivity: Silenor can increase your skin's sensitivity to light from the sun, sunlamps, or tanning beds, leading to severe sunburns, blisters, and swelling. If you are exposed to sunlight, wear sunscreen, protective clothing, and a hat.

Electroconvulsive Therapy (ECT): If you are undergoing ECT, discuss it with your healthcare provider, as Silenor may increase the risk of complications from this therapy.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions.

Common side effects may include:
• Constipation
• Cold symptoms
• Nausea & Vomiting
• Diarrhea
• Dry mouth
• Loss of appetite
• Weight changes
• Numbness or tingling
• Ringing in the ears

Serious side effects may include:
• Silenor may also make depression worse. Inform your doctor if this occurs.
• Serious eye symptoms or swelling
• Serious heart symptoms or pounding heartbeats
• Severe headache, confusion, slurred speech, loss of coordination

Seek immediate medical care or call your doctor if you experience any of the following conditions.

This list does not cover all possible side effects. Consult your doctor for more information on potential side effects.
Is it safe to take it with another drug?
Always inform your doctor about any prescription or over-the-counter (OTC) medications, vitamins, minerals, herbal products, and other supplements you are using. Specifically, make sure to discuss if you are currently using any of the following medications before taking Silenor:
• Monoamine oxidase inhibitor (MAOI) within the last 2 weeks, typically used to treat depression or Parkinson’s disease
• Selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI), commonly prescribed for anxiety and depression
• Antipsychotic medication used for certain mental health conditions
• Medications for managing irregular heart rhythms, such as propafenone, flecainide, or quinidine
• Antihistamine, like chlorpheniramine or diphenhydramine (Benadryl), typically used for an allergy symptoms
• Any other medications that cause dizziness or drowsiness, such as prescription pain relievers, sleep aids, or medications for anxiety
• Cimetidine, often used for indigestion or stomach ulcers.
Many other drugs may affect Silenor blood levels and vice versa. Always inform your doctor about all the medications you are taking or have recently used. This list may not be complete, so always consult your doctor for more information on potential drug interactions.
How should I store it?
Store at room temperature, away from moisture, heat, and light. Keep the bottle tightly closed when not in use.
What action should I take in case of overdose?
Seek immediate medical attention or go to the nearest emergency department. An overdose of Silenor can be life-threatening such as severe hypotension, convulsions, cardiac dysrhythmias.
Is it safe for pregnant or breastfeeding women?

Do not take Silenor during the third trimester of pregnancy without consulting your healthcare provider, as it may harm the unborn baby. Inform your doctor if you are pregnant or planning to become pregnant.

Silenor passes into breast milk, so breast-feeding is not recommended while taking this medication. Tell your doctor if you are breastfeeding or planning to breastfeed, and they will advise you on whether you should continue taking Silenor.

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