Why is Stalevo prescribed?

Carbidopa, Levodopa, and Entacapone (Stalevo) is a combination drug prescribed for the treatment of Parkinson’s disease. It is used to replace Carbidopa and Levodopa treatment when patients are exhibiting symptoms of wearing off (fading effect of the medication). It is also used to substitute individual preparations of Carbidopa, Levodopa, and Entacapone.

What does it do?

Parkinson’s disease is caused by low or inadequate levels of dopamine, which is a chemical messenger in the brain. When dopamine levels are low, symptoms such as muscle stiffness, tremors, slow movement, and balance problems may occur.

Carbidopa is classified as a decarboxylase inhibitor that prevents the premature breakdown of Levodopa for it to be able to reach the brain and exert its effect. Levodopa is classified as a central nervous system agent that is converted to dopamine in the brain. Entacapone is classified as a catechol-O-methyltransferase (COMT) inhibitor that allows increased levels of Levodopa to be present in the brain, making it more effective.

How should I take it?

Stalevo and its generic equivalents are currently available as 12.5/50/200mg, 25/100/200mg, and 37.5/150/200mg tablets. Each tablet should be taken as a whole (do not split) by mouth with or without food.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only use this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Stalevo?

Before taking Carbidopa, Levodopa, and Entacapone, tell your doctor or pharmacist if you have any allergies to food or to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

Inform your doctor about your past and current medical history especially if you have or have had glaucoma, depression, mental illness, stomach ulcer, or liver disease.

For the drug label information of Stalevo, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Diarrhea
• Discoloration of urine
• Dry mouth
• Nausea
• Stomach pain
• Uncontrolled muscle movements
• Vomiting

Serious side effects include:
• Confusion
• Depressed mood
• Fever
• Hallucinations
• Irregular heartbeats
• Lightheadedness
• Severe diarrhea
• Severe nausea and vomiting
• Shortness of breath
• Stiff muscles
• Worsening tremors

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Stalevo with any of the following medications:

• Alprazolam
• Amisulpride
• Biperiden
• Bromocriptine
• Cardizem
• Colcrys
• Cordarone
• Dapsone
• Diamox
• Diazepam
• Epinephrine
• Furazolidone
• Guanabenz
• Isocarboxazid
• Lasix
• Lasmiditan
• Latuda
• Linezolid
• Lipitor
• Midazolam
• Neurontin
• Nitrofurantoin
• Norvasc
• Ozanimod
• Parnate
• Phenelzine
• Pregabalin
• Procarbazine
• Promethazine
• Propoxyphene
• Prozac
• Risperdal
• Seroquel
• Sodium oxybate
• Tegretol
• Tenormin
• Valproic acid
• Xatral
• Ziconotide
• Zocor

If you are using any prescription, non-prescription, and herbal medications, inform your doctor and pharmacist for proper information and ask for other possible interactions not listed within this section.

How should I store it?

Store Stalevo at room temperature (25°C) in a clean environment away from light and moisture, as well as children and pets. Do not refrigerate. Do not remove the desiccant in the original container. Throw away if unused or expired. Do not flush in the toilet. Consult the pharmacist for proper disposal.

What action should I take in case of overdose?

Call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Carbidopa, Levodopa, and Entacapone to determine drug-associated risks of major maternal defects, miscarriages, and fetal outcomes.

Limited data have been established indicating the presence of Carbidopa, Levodopa, and Entacapone in human milk. Consult your doctor first before breastfeeding.

The use of Carbidopa, Levodopa, and Entacapone in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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