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Why is Steglujan prescribed?

Steglujan (Ertugliflozin/Sitagliptin) is prescribed to help control or lower blood sugar levels in individuals with type 2 diabetes mellitus, though it may also be used for other conditions as advised by your healthcare provider.

What does it do?

Steglujan reduces blood sugar levels in adults with type 2 diabetes by utilizing two distinct mechanisms. Ertugliflozin, an SGLT2 (sodium-glucose cotransporter 2) inhibitor, prevents glucose reabsorption in the kidneys, allowing excess sugar to be eliminated through urine. Sitagliptin, a DPP-4 (dipeptidyl peptidase-4) inhibitor, increases incretin hormone levels, promoting insulin release and reducing glucose production in the liver. Together, these actions support better blood sugar control.

How should I take it?

Steglujan should be taken exactly as prescribed by your doctor. Steglujan should be taken once daily, preferably in the morning, with or without food. The recommended starting dose is 5 mg ertugliflozin / 100 mg sitagliptin once daily. If additional blood sugar control is needed, the dose may be increased to 15 mg ertugliflozin / 100 mg sitagliptin once daily. Swallow the whole tablet without crushing or chewing it.

If undergoing surgery or prolonged fasting, Steglujan should be paused for at least 4 days before the procedure and resumed when clinically stable.

What if I missed a dose?

If you miss a dose of Steglujan, take it as soon as you remember. If your next dose is approaching, skip the missed one and continue following your usual schedule. Avoid taking extra or double doses to compensate for the missed dose.

What are the special precautions before taking Steglujan?

Before taking Steglujan, here are several important precautions to keep in mind:

• Do not take Steglujan if you have a known allergy to Ertugliflozin, Sitagliptin, or any of its components.
• Disclose all your current or past medical conditions to your doctor, particularly if you have:
• Pancreatitis
• Gallbladder problems
• Heart failure
• High triglyceride levels
• Liver problems
• Nerve damage or blood flow problems
• Previous amputation
• Genital infections
• Steglujan is not suitable for individuals with severe kidney impairment or those undergoing dialysis, as it may affect kidney function.
• This medication can cause excessive urination, leading to dehydration and low blood pressure.
• Avoid sharing this medication with others, even if they have a similar condition, as it may cause unexpected health risks or adverse effects.
• If you are pregnant, considering pregnancy, or breastfeeding, consult your doctor to understand the potential risks and benefits of taking this medication.
• There is an increased risk of DKA, especially in patients with type 1 diabetes or those on insulin therapy.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Frequent urination
• Upset stomach or diarrhea
• Headache
• Stuffy nose
• Sore throat

Serious side effects may include:
• Genital infections
• Pancreatitis
• Severe dizziness
• Irregular heartbeat
• Swelling of the face, lips, mouth, tongue, or throat

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Steglujan (Ertugliflozin/Sitagliptin) can interact with various medications, so it's important to check for potential interactions before taking it with another drug. Some interactions may increase side effects or reduce effectiveness.

Before taking Steglujan, consult your doctor if you are using any of the following medications:

• Lithium
• Gatifloxacin
• Diuretics (water pill)
• Lisinopril
• Other diabetes medication

This is not a complete list of all the potential drug interactions, always consult your doctor or pharmacist before combining Steglujan with other medications to ensure safety.

How should I store it?

Steglujan should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F to 77°F). Keep it away from direct sunlight and out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Steglujan (Ertugliflozin/Sitagliptin), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital.

Is it safe for pregnant or breastfeeding women?

Steglujan (Ertugliflozin/Sitagliptin) is not advised for use during pregnancy, particularly in the second and third trimesters, due to potential risks to the developing fetus. Animal studies have shown adverse renal effects when exposed during the renal development period, which corresponds to late pregnancy in humans.

For breastfeeding, it is unknown whether Steglujan is excreted into human milk. Its use is also not advised during breastfeeding, as it may impact postnatal kidney development in the infant. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider for guidance on its use to ensure safety for both you and your baby.

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