NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Tasmar prescribed?

Tasmar (Tolcapone) is used as an add-on to carbidopa/levodopa in patients with Parkinson’s disease who experience motor “wearing-off” symptoms such as stiffness, tremors, muscle spasms, or unpredictable off-periods despite optimized levodopa therapy. It’s reserved for those who haven’t achieved adequate symptom control on carbidopa/levodopa alone.

What does it do?

Tolcapone is a catechol-O-methyltransferase (COMT) inhibitor. By blocking COMT, it slows the breakdown of levodopa in the brain and periphery, extending levodopa’s half-life and maintaining steadier dopamine levels to reduce Parkinsonian symptoms.

How should I take it?

Take Tasmar exactly as prescribed by your doctor. The typical dose is a 100 mg tablet orally three times a day, always alongside levodopa/carbidopa, spacing doses approximately every 8 hours at the same times each day.

Swallow tablets whole, with or without food. If the initial dose is well tolerated but insufficient after 3 weeks, your doctor may increase it to 200 mg three times daily, but only if the benefits outweigh the increased risk of liver injury.

What if I missed a dose?

If you miss a dose of Tasmar, take it as soon as you remember. However, if your next scheduled dose is approaching, skip the missed dose and proceed with your usual dosing routine. Do not take extra or double doses to make up for the missed dose.

What are the special precautions before taking Tasmar?

Inform your doctor about all the medications you are taking, your current and previous medical history. Before taking Tasmar, here are several important precautions to keep in mind:

Disclose all your current or past medical conditions to your doctor, particularly if you have:

• Low blood pressure
• Involuntary movements (dyskinesia)
• Liver problems
• Kidney problems
• Psychotic disorder

Monitor for hallucinations, confusion, unusual urges such as gambling, or hypersexuality.

Avoid taking Tasmar if you have used an MAO (Monoamine oxidase) inhibitor within the last 14 days.

If you are pregnant, considering pregnancy, or breastfeeding, consult your doctor to understand the potential risks and benefits of taking this medication.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Diarrhea
• Uncontrolled or involuntary movements (dyskinesia)
• Nausea
• Drowsiness
• Loss of appetite

Serious side effects may include:
• Difficulty breathing
• Severe diarrhea
• Impulse control disorders
• Rhabdomyolysis
• Yellowing of the skin or eyes (jaundice)

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Tasmar (Tolcapone) can interact with various medications, so it's important to check for potential interactions before taking it with another drug. Some interactions may increase side effects or reduce effectiveness.

Before taking Tasmar, consult your doctor if you are using any of the following medications:

• Antidepressants
• Nonselective monoamine oxidase inhibitor (MAOI)
• Methyldopa
• Iloperidone
• Warfarin

This is not a complete list of all the potential drug interactions, always consult your doctor or pharmacist before combining Tasmar with other medications to ensure safety.

How should I store it?

Tasmar should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F to 77°F). Keep the medication in a cool, dry place, away from direct sunlight, and ensure it is kept out of reach of children and pets. Always check the packaging for specific storage instructions and never use it past its expiration date.

What action should I take in case of overdose?

If you suspect an overdose of Tasmar (Tolcapone), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Overdose symptoms may include severe nausea or vomiting, confusion, excessive involuntary movements (dyskinesia), or drowsiness.

Is it safe for pregnant or breastfeeding women?

Tasmar (Tolcapone) should be used with extreme caution during pregnancy and breastfeeding, and only if the potential benefits clearly outweigh the risks. The medication should be used during pregnancy only if absolutely necessary and under close medical supervision. It is also uncertain whether tolcapone passes into human breast milk, but it has been detected in animal milk. Due to the risk of serious liver toxicity and other adverse effects, caution is strongly advised.

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider for guidance on its use to ensure safety for both you and your baby.

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