NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Temodar prescribed?

Temodar is prescribed to treat certain types of brain tumors, specifically:

• Newly diagnosed glioblastoma multiforme (GBM), in combination with radiotherapy and then as maintenance therapy.
• Anaplastic astrocytoma, especially when the tumor has not responded to other treatments.

What does it do?

Temodar is an oral alkylating chemotherapy agent that becomes active in the body by converting into MTIC, a compound that adds methyl groups to DNA, particularly at guanine bases. This DNA damage interferes with the cancer cells’ ability to replicate, ultimately leading to cell death, especially in rapidly dividing tumor cells.

How should I take it?

Always follow your doctor’s instructions or the directions on the product label when taking this medication. The dosing schedule for Temodar varies depending on the type of brain tumor and your doctor’s treatment plan. Common regimens include:

Your healthcare provider will monitor your response and may adjust the dose or pause treatment based on how you tolerate it and any side effects that arise.

What if I missed a dose?

If you miss a dose of Temodar, take it as soon as you remember. However, if your next scheduled dose is approaching, skip the missed dose and proceed with your usual dosing routine. Do not take extra or double doses to make up for the missed dose.

What are the special precautions before taking Temodar?

Inform your doctor about all the medications you are taking, your current and previous medical history and before taking Temodar, here are several important precautions to keep in mind:

Disclose all your current or past medical conditions to your doctor, particularly if you have:

• Liver problems
• Kidney problems
• Low white blood cells (anemia)

This medication increases susceptibility to infections like Pneumocystis pneumonia (PCP), especially if you're also on steroids.

Note also the following precautions:

• Liver enzymes must be monitored, as Temodar can cause serious liver toxicity.
• Avoid donating sperm during treatment with Temodar (Temozolomide) and for at least three months after your final dose.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Nausea
• Loss of appetite
• Fatigue or weakness
• Constipation or diarrhea
• Headache

Serious side effects may include:
• Severe infections
• Myelosuppression
• Secondary cancers
• Yellowing of the skin or eyes (jaundice)
• Swelling of the face, lips, mouth, tongue, or throat

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Temodar (Temozolomide) can interact with various medications, so it's important to check for potential interactions before taking it with another drug. Some interactions may increase side effects or reduce effectiveness.

Before taking Temodar, consult your doctor if you are using any of the following medications:

• Deferiprone
• Etrasimod
• Natalizumab
• Immunosuppressants
• Live vaccines

This is not an exhaustive list of all possible drug interactions. To stay safe, always speak with your doctor or pharmacist before using Temodar alongside any other medications.

How should I store it?

Temodar should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

What action should I take in case of overdose?

If you suspect an overdose of Temodar (Temozolomide), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital.

Is it safe for pregnant or breastfeeding women?

Temodar (Temozolomide) is not considered safe during pregnancy or breastfeeding, and strict precautions are recommended. It has been associated with fetal harm, including birth defects and embryo loss in animal studies. Women should avoid pregnancy during treatment and for at least 6 months after the final dose, while men are advised to use contraception and consider sperm preservation due to the risk of infertility.

Regarding breastfeeding, it is also not recommended during treatment and for at least one week afterward, as the risk of severe side effects in infants, such as myelosuppression, outweighs the uncertain benefit. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider for guidance on its use to ensure safety for both you and your baby.

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