Why is Trental prescribed?

Pentoxifylline (Trental) is prescribed for the management of flow problems in the blood that affects the peripheral parts of the body such as legs and arms. It is also being used to relieve muscle cramps caused by excess lactic acid when exercising and walking.

What does it do?

Pentoxifylline, classified as a xanthine derivative, is a hemorrheologic medication, which primarily works by increasing the pliability of the red blood cells; thus, helping the body to improve blood flow in the peripheral blood vessel through an increase of oxygen levels that is being distributed by the blood to the muscles when exercising.

How should I take it?

Trental is currently available as a 400mg tablet. Each tablet should be taken as a whole (do not split) by mouth with or without food.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Trental?

Before taking Pentoxifylline, tell your doctor or pharmacist if you have any allergies to food or to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

Inform your doctor about your past and current medical history especially if you have or have had coronary artery diseases, blood clots, stroke, eye problems, kidney problem, liver problem and ulcer, particularly in the stomach.

Consult your doctor regarding all the other medications you use before getting surgery.

For the drug label information of Trental, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Anxiety
• Diarrhea
• Dizziness
• Hot flushes
• Insomnia
• Tiredness
• Upset stomach
• Weakness
• Weight loss

Serious side effects include:
• Angina
• Bloody colored urine
• Coughing of blood
• Fluttering of chest
• Light-headedness
• Pounding of heartbeat
• Syncope
• Tarry stools

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Trental with any of the following medications:

• Acarbose
• Acebutolol
• Adalat
• Adesan
• Aldactone
• Alogliptin
• Altace
• Amifostine
• Amikacide
• Asendin
• Bricanyl
• Capomed
• Carafate
• Cipro
• Cordarone
• Coumadin
• Cymbalta
• Diovan
• Entac
• Inoflox
• Isoptin
• Jantoven
• Januvia
• Lotensin
• Luvox
• Methoxsalen
• Mexiletine
• Prozac
• Quinidine
• Samsca
• Sertraline
• Sevo
• Sinemet
• Sumatriptan
• Symmetrel
• Tacrolimus
• Tagamet
• Talinolol
• Tramal
• Tranilast
• Triazolam
• Theophylline
• Valdecoxib
• Ventolin
• Xanor
• Zantac
• Ziprasidone

If you are using any prescription, non-prescription, and herbal medications, inform your doctor and pharmacist for proper information and ask for other possible interactions not listed within this section.

How should I store it?

Store Trental at room temperature (25 °C) in a clean environment away from light and moisture, as well as children and pets. Do not refrigerate. Do not remove the desiccant in the original container. Throw away if unused or expired. Do not flush in the toilet. Consult the pharmacist for proper disposal.

What action should I take in case of overdose?

Call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Pentoxifylline to determine drug-associated risks of major maternal defects, miscarriages and fetal outcomes.

Limited data have been established indicating the presence of  Pentoxifylline in human milk. Consult your doctor first before breastfeeding.

The use of Pentoxifylline in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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