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Why is Uptravi prescribed?

Uptravi is a prescription medication used in the treatment of pulmonary arterial hypertension (PAH), classified under WHO Group I, a condition marked by elevated blood pressure in the arteries connecting the heart to the lungs. Its primary role is to slow disease progression and decrease the likelihood of PAH-related hospitalizations, providing long-term therapeutic support for individuals affected by this serious cardiopulmonary disorder.

What does it do?

Selexipag is a prostacyclin receptor agonist that functions by mimicking the action of prostacyclin, a naturally occurring compound known for its ability to relax and widen blood vessels. When administered, Selexipag specifically targets the pulmonary arteries, causing them to dilate and thus enhancing blood flow through the lungs. This vasodilatory effect helps to reduce the strain on the heart, making it an important therapeutic option in the management of pulmonary arterial hypertension (PAH).

How should I take it?

Always follow your doctor’s instructions or the directions on the product label when taking this medication. Uptravi (Selexipag) is available in two formulations: oral tablets ranging from 200 mcg to 1600 mcg and an intravenous infusion for situations where oral administration is not feasible.

Treatment typically begins with an initial dose of 200 mcg taken twice daily, with dosage increments of 200 mcg each week, as tolerated, up to a maximum of 1600 mcg twice daily. You can take the tablets with or without food, although eating may help reduce stomach upset. Be sure to swallow them whole, without crushing or chewing, to ensure they work properly over time.

What if I missed a dose?

If you forget to take an oral dose of Uptravi, take it as soon as you remember unless your next dose is scheduled within the next six hours. In that case, simply skip the missed dose and continue with your usual dosing routine. Avoid taking two doses at once to make up for the missed one.

If you’ve missed three or more days, contact your healthcare provider, as a dose adjustment may be necessary. For the injection form, if you miss a scheduled appointment, be sure to call your healthcare provider's office promptly to reschedule and maintain consistent treatment.

What are the special precautions before taking Uptravi?

Inform your doctor about all the medications you are taking, your current and previous medical history. Avoid taking Uptravi if you're allergic to Selexipag or any of the ingredients in the medication.

Disclose all your current or past medical conditions to your doctor, particularly if you have:

• Liver problems
• Kidney problems
• Pulmonary veno-occlusive disease

Never share this medication with others, even if their condition seems similar, as it could lead to unforeseen health risks or harmful side effects.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Diarrhea
• Headache
• Jaw pain
• Nausea
• Muscle and joint pain

Serious side effects may include:
• Difficulty breathing
• Pulmonary edema
• Hyperthyroidism
• Severe hypotension

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Uptravi (Selexipag) can interact with various medications, so it's important to check for potential interactions before taking it with another drug. Before taking Uptravi, consult your doctor if you are using any of the following medications:

• Gemfibrozil
• Clopidogrel
• Deferasirox
• Teriflunomide
• Rifampin

This is not a complete list of all the potential drug interactions, always consult your doctor or pharmacist before combining Uptravi with other medications to ensure safety.

How should I store it?

Uptravi should be kept in its original container and stored at room temperature, ideally between 20°C and 25°C (68°F to 77°F), to maintain its effectiveness. Be sure to protect it from excess heat, moisture, and light, and keep it out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Uptravi (Selexipag), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. Overdose symptoms may include severe headache, nausea or vomiting, dizziness or fainting, low blood pressure, or difficulty breathing.

Is it safe for pregnant or breastfeeding women?

Uptravi (Selexipag) is not recommended during pregnancy or breastfeeding due to insufficient human data on safety. While animal studies show no major reproductive harm, potential risks to the fetus or nursing infant cannot be ruled out.

Women of childbearing potential should use effective contraception, and a decision must be made with a healthcare provider to either discontinue the drug or avoid breastfeeding. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider for guidance on its use to ensure safety for both you and your baby.

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