NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Urso prescribed?

Urso (Ursodiol) is a bile acid used to treat small gallstones in individuals who cannot undergo gallbladder surgery, as well as to prevent gallstones in overweight patients experiencing rapid weight loss. It is also prescribed for the treatment of primary biliary cirrhosis (PBC).

What does it do?

Ursodiol is a bile acid that your body naturally produces in small amounts. When taken as a medication, it alters the composition of your bile, allowing cholesterol (a key component of gallstones) to dissolve more easily. This helps break down existing gallstones and prevent new ones from forming. In cases of primary biliary cholangitis (PBC), ursodiol replaces the bile acid that accumulates and causes liver damage.

How should I take it?

Take this medication by mouth with water, following the instructions from your doctor. Take it at the same time every day and continue using it unless your healthcare provider instructs you to stop.

If you are also taking antacids, take them at a different time. Take this medication 1 hour before or 2 hours after taking antacids.

What if I missed a dose?

Take Urso (Ursodiol) as soon as you remember, but if it's nearly time for your next dose, skip the missed dose. Do not double dose.

What are the special precautions before taking Urso?

Before using ursodiol, inform your doctor if you have any of the following conditions:

• A history of unusual or allergic reactions to ursodiol, dyes, bile acids
• Blocked bile duct or fistula
• Pancreatitis
• Pregnant, planning to become pregnant, or breastfeeding

Consult your doctor before using an antacid, and only use the type they recommend.

Regular check-ups with your healthcare team are essential during treatment, as it may take several months to see results. Your care team will monitor the progress of your treatment, including tests to check if your gallstones are dissolving or if your liver condition is improving.

Blood tests may also be required to monitor liver function. Inform your healthcare team if you experience persistent or worsening nausea, vomiting, or abdominal pain.

Does it have any side effects?

Seek emergency medical attention if you experience signs of an allergic reactions with Urso (Ursodiol).

Common side effects may include:
• Back pain
• Diarrhea or constipation
• Cough or sore throat
• Hair loss
• Upset stomach, nausea, or vomiting
• Painful urination
Serious side effects may include:
• Pain or burning during urination
• Stomach pain, discomfort, constipation, or vomiting
• Liver issues, such as nausea, upper stomach pain, itching, fatigue, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes)
• Symptoms of a new infection, including sudden weakness, fever, chills, skin sores, sore throat, mouth sores, or trouble swallowing

This is not an exhaustive list of side effects, and others may occur. Contact your doctor for advice regarding any side effect you may experience.

Is it safe to take it with another drug?
Some drug interactions may cause serious or life-threatening reactions when administered together.
• Antacids
• Cholestyramine
• Clofibrate, fenofibrate, or gemfibrozil
• Colesevelam
• Colestipol
• Estrogen or progestin hormones

This list may not include all potential interactions. Be sure to inform your healthcare provider about all medications. Additionally, let them know if you smoke, consume alcohol as some of these may interact with your medication.

How should I store it?

Store the medication in a tightly closed container at room temperature, away from heat, moisture, and direct light. Avoid freezing. Keep out of children's reach. Do not retain expired or unused medication.

What action should I take in case of overdose?
The common symptom of Ursodiol overdose is diarrhea immediately discontinue the medication and seek medical attention.
Is it safe for pregnant or breastfeeding women?
Urso (Ursodiol) should be used during pregnancy only if prescribed by your doctor. It is unclear whether this medication passes into breast milk, consult your healthcare provider before breastfeeding.
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