Why is Valdoxan prescribed?

Agomelatine (Valdoxan) is prescribed alone or in combination with another medication, for the management of certain neurologic disorders such as anxiety and depression.

What does it do?

Agomelatine, classified as an antidepressant agent, primarily works by blocking the reuptake of the receptor 5-HT2C, which is responsible for the attacks of depressive disorder; hence, increasing the amount of certain neurotransmitters such as Norepinephrine and Dopamine to be released in the frontal cortex of the brain; thus, helping the restoration of the balance of chemicals in the brain and improving the patient’s condition.

How should I take it?

Valdoxan is currently available as a 25mg tablet. Each tablet should be taken as a whole (do not split) by mouth with or without food.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before taking Valdoxan?

Before taking Agomelatine, tell your doctor or pharmacist if you have any allergies to food or to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

Inform your doctor about your past and current medical history especially if you have or have had thrombocytopenia, breathing problems, closed-angle glaucoma, asthma, coronary artery disease, seizure, overactive thyroid, neuroblastoma, ileus, kidney problems, liver problems and schizophrenia.

Avoid drinking alcohol as this may cause dizziness or drowsiness which can add to the effects of Agomelatine.

Consult your doctor regarding all the other medications you use before getting surgery.

For the drug label information of Valdoxan, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Blurred vision
• Constipation
• Dizziness
• Drowsiness
• Dry mouth
• Decreased libido
• Ejaculation problems
• Fatigue
• Impotence
• Insomnia
• Tremors
• Upset stomach

Serious side effects include:
• Agranulocytosis
• Dark colored urine
• Depression
• Enlargement of breast
• Hallucinations
• Hyperglycemia
• Irregular menstruation
• Leukopenia
• Swollen lymph nodes
• Thrombocytopenia
• Unwanted breast milk production

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Valdoxan with any of the following medications:

• Auvi-Q
• Betapace
• Biaxin
• Bromocriptine
• Carbidopa
• Chlorpromazine
• Cipralex
• Cordarone
• Diflucan
• Dopamet
• Dopamine
• Droperidol
• Elavil
• Fluphenazine
• Formoterol
• Goserelin
• Haloperidol
• Itraconazole
• Levodopa
• Lexapro
• Mefloquine
• Methyldopa
• Nizoral
• Nortriptyline
• Plasil
• Primozide
• Procainamide
• Quinidine
• Saquinavir
• Silenor
• Xanor

If you are using any prescription, non-prescription, and herbal medications, inform your doctor and pharmacist for proper information and ask for other possible interactions not listed within this section.

How should I store it?

Store Valdoxan at room temperature (25°C) in a clean environment away from light and moisture, as well as children and pets. Do not refrigerate. Do not remove the desiccant in the original container. Throw away if unused or expired. Do not flush in the toilet. Consult the pharmacist for proper disposal.

What action should I take in case of overdose?

Call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Agomelatine to determine drug-associated risks of major maternal defects, miscarriages and fetal outcomes.

Limited data have been established indicating the presence of Agomelatine in human milk. Consult your doctor first before breastfeeding.

The use of Agomelatine in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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