NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Vastarel MR prescribed?

Vastarel MR is prescribed primarily for the symptomatic relief of stable angina pectoris in individuals who either cannot tolerate or have not responded adequately to standard first-line treatments. Additionally, it may be used to manage symptoms such as dizziness, ringing in the ears (tinnitus), and certain visual disturbances that stem from vascular disorders.

What does it do?

Vastarel MR works by optimizing the heart’s energy metabolism, specifically enhancing glucose utilization in the myocardium. It achieves these results by inhibiting the enzyme long-chain 3-ketoacyl CoA thiolase, which suppresses fatty acid oxidation and promotes glucose oxidation. This metabolic shift supports cardiac function during periods of reduced oxygen supply (ischemia) without altering blood pressure or heart rate.

How should I take it?

Always follow your doctor’s instructions the usual dose of 20mg three times a day. The dose is one tablet of 35mg of Trimetazidine twice daily during meals.

What if I missed a dose?

If you forget to take your dose of Vastarel MR, take it as soon as you remember. If it’s nearly time for your next scheduled dose, skip the one you missed and continue with your regular dosing schedule. Avoid taking additional or double doses, as this can increase the risk of adverse effects.

What are the special precautions before taking Vastarel MR?

Inform your doctor about all the medications you are taking, your current and previous medical history. Before taking Vastarel MR, here are several important precautions to keep in mind:

Do not take Vastarel MR if you're allergic to Trimetazidine or to any other ACE (angiotensin converting enzyme) inhibitor medications.

Disclose all your current or past medical conditions to your doctor, particularly if you have:

• Severe renal impairment (creatinine clearance <30 mL/min)
• Parkinson’s disease
• Other movement disorders

Avoid sharing Vastarel MR with others even if their condition appears similar, as doing so may result in unexpected health risks or dangerous side effects.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Abdominal pain
• Dizziness
• Headache
• Nausea
• Diarrhea

Serious side effects may include:
• Allergic reaction
• Hepatitis
• Skin rashes
• Tremors

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Vastarel MR (Trimetazidine) hasn’t shown significant interactions with common cardiovascular medications like beta-blockers, calcium antagonists, nitrates, heparin, statins, or digitalis, it's still essential to inform your doctor of all medicines you're taking to safeguard against any unexpected or subtle interactions. Transparency with your healthcare provider helps keep your treatment both safe and effective.

How should I store it?

Vastarel MR should be kept in its original container and stored at room temperature, ideally between 20°C and 25°C (68°F to 77°F), to maintain its effectiveness. Be sure to protect it from excess heat, moisture, and light, and keep it out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Vastarel MR (Trimetazidine), it's important to act quickly and seek immediate medical attention. Call emergency services or go to the nearest hospital, especially if severe symptoms occur, such as confusion, fainting, tremors, or difficulty breathing.

Is it safe for pregnant or breastfeeding women?

Vastarel MR (Trimetazidine) is not recommended during pregnancy or breastfeeding due to insufficient clinical data on its safety in these populations. Although animal studies have not shown teratogenic effects, its use should be avoided unless clearly necessary, and breastfeeding should be discontinued if treatment is essential.

If you're pregnant, considering pregnancy, or currently breastfeeding, it's important to speak with your healthcare provider to ensure that using this medication is safe for both you and your child.

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