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Why is Velsipity prescribed?

Velsipity is prescribed to manage moderate to severe cases of active ulcerative colitis in individuals aged 16 years and above, including both adolescents and adults. It is used when conventional therapies or biologics have failed, lost effectiveness, or are unsuitable.

What does it do?

Velsipity acts as a sphingosine-1-phosphate receptor modulator by inhibiting the movement of lymphocytes, a type of white blood cell, from the lymph nodes into the circulatory system. This action limits the migration of immune cells to the intestinal lining, thereby reducing inflammation in the colon.

How should I take it?

Always follow your doctor’s instructions, or the directions on the product label when taking this medication. The recommended dosage is one 2 mg tablet taken orally once daily. During treatment with Velsipity, each tablet should be swallowed whole and may be taken either with or without food. However, to help minimize the potential for heart rate reduction, it is recommended to take the medication with food for the first three days of therapy.

What if I missed a dose?

If you miss a dose of Velsipity, it is important not to take a double dose to make up for it. Instead, simply take the next scheduled dose at the usual time to maintain the prescribed dosing regimen and ensure consistent therapeutic effect.

What are the special precautions before taking Velsipity?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Avoid taking Velsipity if you had a heart attack, stroke, or severe heart failure in the past 6 months.

Disclose all your current or past medical conditions to your doctor, particularly if you have:

• Slow heart rate
• Irregular heartbeat
• Heart problems
• Stroke
• Repeated fainting
• Liver problems
• Skin cancer
• Sleep apnea
• Weak immune system (immunocompromised)

Avoid taking Velsipity if you have certain heart rhythm disorders without a pacemaker.

Velsipity may impair coordination, so it is advised not to drive, operate machinery, or engage in any activities that require physical coordination until you understand how the medication affects you personally.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Dizziness
• Headache
• Elevated liver enzymes
• Nausea
• Joint pain

Serious side effects may include:
• Infections such as meningitis
• Bradycardia (slow heart rate)
• Macular edema
• High blood pressure
• Liver damage

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Velsipity (Etrasimod) has the potential to interact with a wide range of medications, which can either heighten the risk of side effects or diminish its therapeutic effectiveness. To ensure safety and optimal treatment outcomes, it's essential to consult your healthcare provider before combining Velsipity with any other drug.

Before taking Velsipity, consult your doctor if you are using any of the following medications:.

• Beta-blockers or calcium channel blockers
• Immunosuppressants
• Fluconazole
• Rifampin
• Diltiazem
• Medications for cancer

This is not a full list of possible drug interactions. To ensure your safety, it's essential to speak with your doctor or pharmacist before taking Velsipity alongside other medications, including over-the-counter drugs or supplements.

How should I store it?

Velsipity should be kept in its original container and stored at room temperature, ideally between 20°C and 25°C (68°F to 77°F), to maintain its effectiveness.

What action should I take in case of overdose?

In case of a Velsipity (Etrasimod) overdose, seek immediate medical attention or contact emergency services, as serious complications may occur. Overdose symptoms can include severe dizziness, fainting, slow or irregular heartbeat, confusion, vision changes, breathing difficulties, and seizures.

Is it safe for pregnant or breastfeeding women?

Velsipity (Etrasimod) is not considered safe for use during pregnancy, as animal studies have demonstrated potential harm to the fetus, including malformations and impaired fertility. Women of reproductive potential are advised to use effective contraception throughout the treatment period and for a minimum of seven to fourteen days after discontinuing the medication.

Regarding breastfeeding, the safety of Velsipity is uncertain. Although it has been detected in the milk of treated animals, it remains unknown whether it passes into human breast milk. Consequently, caution is recommended, particularly when breastfeeding newborns or premature infants.

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