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Why is Vetmedin prescribed?

Vetmedin is given to dogs to help manage congestive heart failure (CHF) caused by myxomatous mitral valve disease (MMVD), which is a condition that weakens the mitral valve, or dilated cardiomyopathy (DCM), which affects how well the heart muscle works. Additionally, it may be used to help delay the onset of CHF in dogs diagnosed with preclinical MMVD.

What does it do?

Vetmedin works through a dual mechanism of action:

• Positive inotropy: Increases the heart muscle's ability to contract by enhancing calcium sensitivity
• Vasodilation: Relaxes blood vessels by inhibiting phosphodiesterase III, reducing the workload on the heart

Together, these mechanisms improve cardiac output and relieve the clinical signs of heart failure, making it a valuable therapeutic option for canine cardiac care.

How should I take it?

Always follow your doctor’s instructions, or the directions on the product label when taking this medication. Vetmedin should be administered orally to dogs, either as chewable tablets or in an oral solution. The standard dosage is typically 0.5 mg/kg/day, split into two doses given 12 hours apart. It's best to give the medication on an empty stomach, roughly one hour before feeding. Always follow your veterinarian's specific instructions regarding dosage and timing to ensure the best outcome for your pet’s heart health.

What if I missed a dose?

If a dose of Vetmedin is missed, it's generally advised to administer it as soon as you remember. However, if it's nearly time for the next scheduled dose, skip the missed one and continue with the regular dosing routine. Doubling up on doses is not recommended, as this may increase the risk of side effects.

Always follow your veterinarian’s guidance when handling missed doses to keep your pet’s heart health safely on track.

What are the special precautions before taking Vetmedin?

Inform your doctor about all the medications you are taking, your current and previous medical history.

• Vetmedin is intended solely for veterinary use and should never be used by humans.
• Vetmedin should not be used in dogs with:
• Hypertrophic cardiomyopathy
• Aortic stenosis
• Conditions where increased cardiac output is inappropriate
• Avoid sharing Vetmedin with others even if their dog’s condition appears similar, as doing so may result in unexpected health risks or dangerous side effects.
• Vetmedin should be used with caution in dogs under 6 months of age, as well as in pregnant, lactating, or breeding dogs.
• After using this product, be sure to wash your hands thoroughly. Since it may cause eye irritation, avoid getting it in your eyes.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Decreased appetite
• Vomiting
• Diarrhea
• Lethargy

Serious side effects may include:
• Difficulty breathing
• Syncope (fainting)
• Arrhythmias
• Sudden death

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your veterinarian.

Is it safe to take it with another drug?

Vetmedin (Pimobendan) has the potential to interact with a wide range of medications, which may either increase the risk of side effects or reduce its therapeutic effectiveness.

Before using Vetmedin, consult your doctor if your dog is using any of the following medications:

• Diltiazem
• Atenolol
• Furosemide
• Enalapril
• Digoxin

This is not a full list of possible drug interactions. To ensure your dog’s safety, it's essential to speak with your dog’s doctor before combining Vetmedin alongside other medications.

How should I store it?

Vetmedin should be kept in its original container and stored at room temperature, ideally between 20°C and 25°C (68°F to 77°F), to maintain its effectiveness. Be sure to protect it from excess heat, moisture, and light, and keep it out of reach of children and pets. Always check the packaging for specific storage instructions and never use it past its expiration date.

What action should I take in case of overdose?

In the case of a Vetmedin (Pimobendan) overdose, you should seek immediate veterinary attention, as overdose can lead to serious complications such as vomiting, diarrhea, weakness, difficulty breathing, collapse, seizures, or sudden death.

Is it safe for pregnant or breastfeeding dogs?

Vetmedin (Pimobendan) is not recommended for use in pregnant or lactating dogs, as its safety has not been established in these populations. Although animal studies have not shown teratogenic effects, they have indicated maternotoxic and embryotoxic risks at high doses, and pimobendan is known to be excreted into milk.

Therefore, administration should only occur if the expected therapeutic benefits outweigh the potential risks and always under veterinary supervision.

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