Vetoryl is the only FDA-approved medication for treating Cushing’s disease (hyperadrenocorticism) in both dogs and cats, specifically targeting the two main forms of the condition: pituitary-dependent and adrenal-dependent hyperadrenocorticism.

What does it do?

Vetoryl contains trilostane, a synthetic steroid that works by inhibiting the enzyme 3ß-hydroxysteroid dehydrogenase in the adrenal cortex. This action helps block the production of cortisol, a hormone that is excessively produced in both dogs and cats with Cushing’s disease, thereby reducing clinical symptoms. However, it's important to note that Vetoryl controls the disease by lowering cortisol levels but does not treat the underlying tumor causing the condition.

How should I take it?

Always follow your doctor’s instructions, or the directions on the product label when taking this medication. Vetoryl should be administered orally to both dogs and cats once daily, ideally in the morning, and always with food to enhance absorption. The dosage is based on body weight, typically starting at 2.2 to 6.7 mg/kg. Capsules must be given whole, without crushing or breaking.

What if I missed a dose?

If a dose of Vetoryl is missed, it's generally advised to administer it as soon as you remember. However, if it's nearly time for the next scheduled dose, skip the missed one and continue with the regular dosing routine. Doubling up on doses is not recommended, as this may increase the risk of side effects. Always consult your veterinarian before making any changes to the treatment plan.

What are the special precautions before taking Vetoryl?

Inform your doctor about all the medications you are taking, your current and previous medical history.

• Vetoryl is intended solely for veterinary use and should never be used by humans.
• Vetoryl should not be used in both dogs and cats with:
• Primary liver or kidney disease
• Pregnancy or lactation
• Weight under 3 kg
• Known hypersensitivity to Trilostane
• Enhanced sensitivity to Vetoryl capsules may occur in dogs or cats with a history of mitotane treatment, making close monitoring of adrenal function essential throughout therapy.
• Avoid sharing Vetoryl with others even if their pet’s condition appears similar, as doing so may result in unexpected health risks or dangerous side effects.
• Pregnant women should not handle the capsules due to anti-progesterone effect.
• After using this product, be sure to wash your hands thoroughly. Since it may cause eye irritation, avoid getting it in your eyes.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Diarrhea
• Lethargy
• Loss of appetite
• Weakness

Serious side effects may include:
• Hypoadrenocorticism (Addisonian crisis)
• Adrenal necrosis
• Severe lethargy
• Sudden death

This is not a full list of possible drug interactions. To ensure your dog’s safety, it's essential to speak with your pet’s doctor This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your veterinarian.

Is it safe to take it with another drug?

Vetoryl (Trilostane) has the potential to interact with a wide range of medications, which may either increase the risk of side effects or reduce its therapeutic effectiveness.

Before using Vetmedin, consult your doctor if your dog or cat is using any of the following medications:

• Enalapril
• Benazepril
• Spironolactone
• Potassium supplements
• Ketoconazole or mitotane

How should I store it?

Vetoryl should be kept in its original container and stored at room temperature, ideally between 20°C and 25°C (68°F to 77°F), to maintain its effectiveness. Be sure to protect it from excess heat, moisture, and light, and keep it out of reach of children and pets. Always check the packaging for specific storage instructions and never use it past its expiration date.

What action should I take in case of overdose?

In case of a Vetoryl (Trilostane) overdose, you should immediately stop administering the medication and contact your veterinarian or an emergency veterinary facility. Overdose can lead to severe adrenal suppression, resulting in symptoms of hypoadrenocorticism (Addisonian crisis), such as lethargy or collapse, vomiting, diarrhea with bloody stool, loss of appetite, or weakness.

Is it safe for pregnant or breastfeeding dogs or cats?

Vetoryl (Trilostane) is not safe for use in pregnant or lactating dogs or cats. It is strictly contraindicated during pregnancy and nursing because trilostane has anti-progesterone properties that can interfere with hormone levels essential for maintaining pregnancy and fetal development. Use in breeding animals is also discouraged due to potential effects on fertility. Always inform your veterinarian if your pet is pregnant, nursing, or intended for breeding before starting treatment.

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