NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Vimovo prescribed?

Vimovo is used to treat pain and inflammation associated with conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and juvenile idiopathic arthritis. It also helps protect against gastric ulcers in individuals who need NSAID therapy and face a higher likelihood of developing NSAID-related ulcers.

What does it do?

Vimovo combines two active ingredients:

• Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that blocks enzymes (COX-1 and COX-2) responsible for producing prostaglandins, which cause pain, inflammation, and fever.
• Esomeprazole is a proton pump inhibitor (PPI) that reduces stomach acid, thereby protecting the stomach lining from irritation and ulceration caused by naproxen.

This dual-action formulation is especially beneficial for patients who need long-term NSAID treatment but are at increased risk of developing NSAID-induced gastric ulcers.

How should I take it?

Always follow your doctor’s instructions, or the directions on the product label when taking this medication. Vimovo should be taken as one tablet twice daily, at least 30 minutes before meals, to ensure optimal effectiveness.

Each tablet must be swallowed whole with water. Do not crush, chew, or split the tablets to preserve their protective formulation. It's important to use the lowest effective dose for the shortest duration necessary, as advised by your healthcare provider, to minimize potential risks associated with prolonged NSAID use.

What if I missed a dose?

If a dose of Vimovo is missed, take it as soon as you remember, unless it's already close to the time for your next scheduled dose. In that case, simply skip the missed dose and continue with your regular dosing routine. Avoid taking additional or double doses, as this can increase the risk of adverse effects.

What are the special precautions before taking Vimovo?

Before taking Vimovo, here are several important precautions to keep in mind:

• Do not take Vimovo if you're allergic to Naproxen, Esomeprazole, other NSAIDs, or any of the ingredients in the medication.
• Disclose all your current or past medical conditions to your doctor, particularly if you have:
• Asthma
• Heart disease
• High blood pressure
• History of stroke
• Lupus erythematosus
• Inflammatory bowel disease
• Kidney or liver impairment
• Fluid retention (edema)
• Bleeding problems
• Vimovo should not be used by individuals under the age of 12 or those who weigh less than 38 kilograms (84 pounds), as it has not been approved for these groups.
• It’s advised to avoid using Vimovo right before or after undergoing coronary artery bypass graft (CABG) surgery due to the heightened risk of severe cardiovascular issues during that time.
• Talk to your doctor before taking this medicine if you are pregnant, planning to become pregnant, or breastfeeding. Your doctor can help you weigh the potential benefits and risks for both you and your baby.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Stomach discomfort
• Diarrhea
• Headache
• Nausea

Serious side effects may include:
• Heart attack or stroke
• Stomach bleeding or ulcers
• Severe skin reactions
• Anemia
• Bone fractures

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Vimovo (Naproxen/Esomeprazole) has the potential to interact with a wide range of medications, which can either heighten the risk of side effects or diminish its therapeutic effectiveness.

Before taking Vimovo, consult your doctor if you are using any of the following medications:

• Aspirin
• Blood thinners
• Diuretics
• Digoxin
• Rifampin
• Heart or blood pressure medications

This is not a full list of possible drug interactions. To ensure your safety, it's essential to speak with your doctor or pharmacist before taking Vimovo alongside other medications, including over-the-counter drugs or supplements.

How should I store it?

Vimovo should be kept in its original container and stored at room temperature, ideally between 20°C and 25°C (68°F to 77°F), to maintain its effectiveness. Be sure to protect it from excess heat, moisture, and light, and keep it out of reach of children and pets. Always check the packaging for specific storage instructions and never use it past its expiration date.

What action should I take in case of overdose?

In case of an overdose of Vimovo (Naproxen/Esomeprazole), seek emergency medical attention immediately or go to the nearest hospital. Symptoms of overdose may include drowsiness, severe weakness, stomach pain, and vomiting.

Is it safe for pregnant or breastfeeding women?

Vimovo is not recommended for use during pregnancy, especially after 20 weeks' gestation, due to risks such as premature closure of the fetal ductus arteriosus and fetal kidney complications, which may lead to oligohydramnios and neonatal renal impairment. During breastfeeding, naproxen, a component of Vimovo, is excreted into breast milk and may pose risks to the infant, including somnolence and rare but serious effects like coagulation disturbances.

Therefore, use in nursing mothers should be avoided, and safer alternatives should be considered. If you're pregnant, considering pregnancy, or currently breastfeeding, it's important to speak with your healthcare provider to ensure that using this medication is safe for both you and your child.

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