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Vraylar (Cariprazine) is a prescription medication prescribed to adults for the following purposes:

• In combination with antidepressants to treat major depressive disorder (MDD)
• For short-term treatment of manic or mixed episodes associated with bipolar I disorder
• To treat depressive episodes related to bipolar I disorder (bipolar depression)

What does it do?

Vraylar works by regulating serotonin and dopamine levels in the brain. It acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and an antagonist at serotonin 5-HT2A receptors. It is classified as an atypical anti-psychotic.
How should I take it?
Take Vraylar orally with a glass of water, following the instructions on the prescription label which is the usual starting dose is 1.5mg and will always depend on your doctor’s direction. You can take it with or without food. Be sure to take it at consistent intervals and do not take more than prescribed. Only stop taking it if directed by your doctor.
What if I missed a dose?
If you miss a dose, take it as soon as possible. However, if it's nearly time for your next dose, skip the missed dose and take only the scheduled one. Do not take two doses at once or more than prescribed.
What are the special precautions before taking Vraylar?

Vraylar should not be used if you are allergic to Cariprazine and is not approved for individuals under 18 years old. It is also not recommended for older adults with dementia-related psychosis due to an increased risk of death.

Before taking Vraylar, inform your doctor if you have:
• A history of stroke or blood clots
• Dehydration
• Heart disease or high blood pressure
• High cholesterol or triglycerides
• Liver or kidney disease
• Diabetes, high blood sugar, or a family history of these conditions
• A history of low white blood cell counts or seizures
• Liver or kidney disease

Vraylar may affect the body's ability to regulate its core temperature, so caution is advised during strenuous exercise, heat exposure, dehydration, or when taking anticholinergic medications.

Additionally, Vraylar combined with antidepressants may increase the risk of suicidal thoughts or actions in children and young adults, particularly during the first few months of treatment or when doses are adjusted. Mental illnesses like depression are key contributors to these risks.

Does it have any side effects?
It is important to note that all drugs have corresponding side effects and adverse reactions
Common side effects may include:
• A history of stroke or blood clots
• Constipation
• Drowsiness
• Dizziness
• Fatigue
• Indigestion
• Involuntary muscle movements, or slow movements
• Nausea & Vomiting
• Trouble sleeping
• Increased appetite
• Restlessness
• Upset stomach
Serious side effects may include:
• Delayed Side Effects: Some effects may not appear immediately and can occur weeks after starting or adjusting the dose. Monitoring by your healthcare provider is necessary.
• Difficulty Swallowing: May lead to food or liquid entering the lungs, increasing the risk of choking or aspiration.
• Drowsiness and Cognitive Effects: Vraylar may cause tiredness, drowsiness, and difficulty with normal activities. Avoid driving or operating heavy machinery until you know how it affects you.
• Tardive Dyskinesia (TD): Uncontrolled movements of the face, tongue, or other parts of the body, which may persist even after stopping the medication.
• Low White Blood Cell Count: Increases the risk of infections, and very low counts can be fatal. Regular blood tests may be needed.
• Falls: Due to sleepiness, dizziness, or decreased blood pressure, which can lead to injuries.
• Increased Body Temperature: Avoid overheating, dehydration, and excessive exercise. Stay cool and drink plenty of water during treatment.
• Seizures: Convulsions are a potential risk.
• Stroke
• Tardive Dyskinesia (TD): Uncontrolled movements of the face, tongue, or other parts of the body, which may persist even after stopping the medication.

Vraylar may have long-term effects, and some side effects could persist for weeks after stopping the medication or changing your dose. It’s important to closely monitor these potential side effects and seek medical advice if any occur.

Is it safe to take it with another drug?

Some drug interactions may cause serious or life-threatening reactions when administered together.

Do not take Vraylar together with this medication:

• Metoclopramide
Vraylar may also interact with:
• Antihistamines
• Carbamazepine
• Certain medications for anxiety or sleep
• Amitriptyline
• Fluoxetine
• Sertraline
• Itraconazole
• Halothane
• Isoflurane
• Methoxyflurane
• Propofol
• Rifampin
• Thioridazine
This list may not include all possible interactions. Be sure to provide your healthcare provider with a list of all the medications, herbs, over-the-counter drugs, and dietary supplements you are using.
How should I store it?
Store the medication at room temperature, away from light. Keep it out of reach of children.
What action should I take in case of overdose?
Overdose of Vraylar may cause hypotension, monitor your vital signs and contact your doctor or go to the emergency room immediately.
Is it safe for pregnant or breastfeeding women?

Taking anti-psychotic medication during the last three (3) months of pregnancy may lead to withdrawal symptoms, feeding issues, irritability, breathing difficulties, tremors, and weak or stiff muscles in the newborn. If you become pregnant, inform your doctor immediately. Do not stop taking Vraylar without consulting your doctor.

Breastfeeding while using this medication may not be safe. Consult your doctor about the potential risks.

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