Xalkori is prescribed to treat certain cancers characterized by specific genetic mutations. These include ALK-positive or ROS1-positive non-small cell lung cancer (NSCLC), ALK-positive anaplastic large cell lymphoma (ALCL) in children and young adults, and ALK-positive inflammatory myofibroblastic tumor (IMT) that cannot be surgically removed.

What does it do?

Xalkori is a tyrosine kinase inhibitor that blocks abnormal proteins produced by mutations in the ALK or ROS1 genes, which are proteins that drive cancer cell growth and survival. By targeting and inhibiting these proteins, Xalkori slows tumor progression and may trigger cancer cell death.

How should I take it?

Take 250 mg of Xalkori orally twice daily, with or without food. Swallow the capsules whole without crushing, chewing, or splitting them. If using oral pellets, pour them directly into your mouth or onto a spoon, then follow with water. Always follow your doctor’s instructions carefully and attend regular checkups to monitor your progress.

What if I missed a dose?

If a dose of Xalkori is missed, take it as soon as you remember, unless it's already close to the time for your next scheduled dose. In that case, simply skip the missed dose and continue with your regular dosing routine. If vomiting occurs after a dose, do not retake it, simply continue with your next scheduled dose. Avoid taking additional or double doses, as this can increase the risk of adverse effects.

What are the special precautions before taking Xalkori?

Inform your doctor about all the medications you are taking, your current and previous medical history. Before taking Xalkori, here are several important precautions to keep in mind:

• Do not take Xalkori if you're allergic to Crizotinib or any of the ingredients in the medication.
• Disclose all your current or past medical conditions to your doctor, particularly if you have:
• Liver problems
• Kidney problems
• Lung or breathing problems
• Vision problems
• Heart conditions such as QT prolongation
• A bradycardia (symptomatic) can occur in while receiving this medication.
• Xalkori may impair your alertness or coordination. Avoid driving or engaging in activities that require full attention or physical coordination until you understand how this medication affects you.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Nausea
• Diarrhea
• Constipation
• Dizziness
• Headache

Serious side effects may include:
• Lung inflammation
• Heart rhythm changes
• Yellowing of the skin or eyes (jaundice)
• Severe vision loss
• Difficulty breathing

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Xalkori (Crizotinib) has the potential to interact with a wide range of medications, which can either heighten the risk of side effects or diminish its therapeutic effectiveness.

Before taking Xalkori, consult your doctor if you are using any of the following medications:

• St. John’s wort
• Ketoconazole
• Digoxin
• Rifampin
• Grapefruit products

This is not a full list of possible drug interactions. To ensure your safety, it's essential to speak with your doctor or pharmacist before taking Xalkori alongside other medications, including over-the-counter drugs or supplements.

How should I store it?

Xalkori should be kept in its original container and stored at room temperature, ideally between 20°C and 25°C (68°F to 77°F), to maintain its effectiveness. Be sure to protect it from excess heat, moisture, and light, and keep it out of reach of children and pets. Always check the packaging for specific storage instructions and never use it past its expiration date.

What action should I take in case of overdose?

In case of a Xalkori (Crizotinib) overdose, you should seek immediate medical attention by contacting your local emergency services or going to the nearest hospital. Overdose symptoms may include severe nausea, vomiting, diarrhea, vision disturbances, dizziness, and potential liver or heart complications.

Is it safe for pregnant or breastfeeding women?

Xalkori is not safe for use during pregnancy or breastfeeding. It can cause harm to an unborn baby, so women should avoid becoming pregnant while taking the medication and for at least 45 days after the last dose. Men with female partners of reproductive potential should use effective contraception during treatment and for 90 days after the last dose.

Breastfeeding is not advised during treatment and for 45 days after stopping Xalkori due to infant risk. If you're pregnant, considering pregnancy, or currently breastfeeding, it's important to speak with your healthcare provider to ensure that using this medication is safe for both you and your child.

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