Xeomin (Incobotulinumtoxina) is commonly used to treat the following conditions:

• Excessive saliva production (sialorrhea)
• Muscle stiffness in the arms caused by spasticity
• A painful movement disorder where the head twists or is pulled backward or forward due to muscle contractions in the neck (cervical dystonia)
• Abnormal eyelid spasms (blepharospasm)
• To temporarily reduce the appearance of moderate to severe frown lines between the eyebrows (glabellar lines), crow's feet (lateral canthal lines), and forehead lines
What does it do?
It is an injectable medication under drug class neuromuscular blocker that contains toxin bacteria (Clostridium botulinum).
• For sialorrhea, Xeomin helps reduce saliva production by inhibiting the release of acetylcholine, a natural chemical in your body that stimulates saliva production.
• For cervical dystonia, spasticity, and blepharospasm, Xeomin works by blocking specific nerve signals, which decreases muscle activity at the injection site.
• For wrinkles, Xeomin temporarily improves the appearance of lines on your face by reducing muscle activity in the treated area.
How should I take it?
Xeomin is injected into the muscles by a healthcare provider, typically in a clinic or hospital, as the procedure requires professional training. The dosage and number of injections depend on the condition being treated, and your healthcare provider will determine the appropriate treatment plan.
What if I missed a dose?
Xeomin is typically administered by a healthcare provider in a clinic, who will ensure that you receive your doses as scheduled. If you miss an appointment for your Xeomin dose, contact the clinic as soon as possible to reschedule.
What are the special precautions before taking Xeomin?

Before using Xeomin, inform your healthcare provider if you have any of the following:

• Muscle or nerve disorders (e.g., ALS, myasthenia gravis, or Lambert-Eaton syndrome)
• Breathing issues (e.g., asthma or emphysema)
• Difficulty swallowing
• A history of facial or eye surgery
• Bleeding disorders
• Muscle weakness near the injection site
• Drooping eyelids or eyebrows
• Changes in facial appearance

Xeomin should not be injected into skin with an infection. If you have symptoms of a skin infection (e.g., redness, pain, swelling, warmth, or blisters), tell your healthcare provider.

Xeomin may cause muscle weakness, loss of strength, vision issues, or drooping eyelids shortly after the injection. If this occurs, avoid activities that require alertness or coordination, such as driving.

Does it have any side effects?

The most frequent side effects of Xeomin can vary based on factors like your age, the condition being treated, and where you receive the injection. Let your healthcare provider know if any of these side effects trouble you:

Common side effects may include:
• Dry mouth
• High blood pressure
• Headache
• Nausea, vomiting, or diarrhea
• Seizures
• Bronchitis, sore throat, or cold-like symptoms
• Trouble swallowing
• Neck, muscle, or joint pain
• Muscle weakness
• Pain or bruising at the injection site
• Eye issues, including dry eyes, blurred vision, or dropping eyelids
Serious side effects may include:
• Spread of Toxin Effects: The effects of Xeomin may spread from the injection site and cause botulism
• Severe Allergic Reactions
• Breathing, Swallowing, or Speaking Problems
• Eye Surface Issues
There may be additional side effects not listed here. If you suspect you're experiencing a side effect from Xeomin, contact your healthcare provider for advice.
Is it safe to take it with another drug?

Always inform your healthcare provider about any prescription and supplements you are using.

Specifically, discuss if you are using any of the following before using Xeomin:

• Any botulinum toxin products, such as Myobloc (rimabotulinumtoxinB), Dysport (abobotulinumtoxinA), Daxxify (daxibotulinumtoxinA), Botox (onabotulinumtoxinA), or Jeuveau (prabotulinumtoxinA) for wrinkles or spasms.
• Aminoglycoside antibiotics like amikacin or gentamicin, which are injected to treat infections.
• Anticholinergic medicines, including antihistamines and those used for Parkinson’s disease, overactive bladder, or stomach issues.
• Muscle relaxants, such as cyclobenzaprine, carisoprodol (Soma), or tizanidine (Zanaflex).
• Sleep medications, like zolpidem (Ambien), temazepam (Restoril), or eszopiclone (Lunesta).
• Aspirin, commonly found in pain, swelling, and fever medications.
• Antiplatelet medications, such as ticagrelor (Brilinta), aspirin/dipyridamole, clopidogrel (Plavix), or cilostazol, which prevent blood clots.
• Blood thinners used to treat or prevent blood clots
This is not an exhaustive list of possible drug interactions with Xeomin. Always consult your healthcare provider for more information.
How should I store it?
Xeomin is typically administered by a doctor in a hospital or clinic. If you need to store Xeomin at home, be sure to follow the storage instructions provided by your doctor.
What action should I take in case of overdose?
If you suspect a Xeomin overdose, seek immediate medical attention. Overdose symptoms may include muscle weakness, breathing or swallowing difficulties, vision issues, or drooping eyelids. Prompt action is crucial to prevent complications. Always follow your healthcare provider's guidance and attend follow-up appointments to ensure safe use of Xeomin.
Is it safe for pregnant or breastfeeding women?

Pregnancy: It is unclear whether Xeomin could impact pregnancy or harm an unborn baby. Inform your doctor if you are pregnant or planning to become pregnant.

Breastfeeding: It is unknown if Xeomin passes into breast milk. Let your doctor know if you are breastfeeding or intend to breastfeed. They will provide guidance on whether you should use Xeomin while breastfeeding.

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