Xerese is prescribed for the early treatment of recurrent cold sores (herpes labialis) in adults and children aged 6 years and older. It helps shorten healing time and reduce the chance of cold sores becoming ulcerative.

What does it do?

Xerese combines acyclovir, an antiviral that inhibits herpes virus replication, with hydrocortisone, a corticosteroid that reduces inflammation, redness, and swelling. Together, these ingredients help relieve symptoms and reduce the severity and duration of lesions.

Why is Xerese Cream prescribed?

Always follow your doctor’s instructions, or the directions on the product label when taking this medication. To use Xerese effectively, begin treatment at the first sign of a cold sore, such as tingling, itching, or redness. Apply a thin layer to the affected area five times daily for five days.

Be sure to wash your hands before and after each application, avoid rubbing the cold sore or covering it with a bandage, and refrain from applying cosmetics, lip balm, or sunscreen to the treated area.

What if I missed a dose?

If a dose of Xerese Cream is missed, apply it as soon as you remember, unless it's already close to the time for your next scheduled dose. In that case, simply skip the missed application and continue with your regular dosing routine. Never apply extra Xerese Cream to make up for a missed dose, as doubling up may lead to skin irritation without enhancing the treatment’s effectiveness.

What are the special precautions before taking Xerese Cream?

Inform your doctor about all the medications you are taking, your current and previous medical history.

Do not take Xerese Cream if you're allergic to Acyclovir, Hydrocortisone, or any of the ingredients in the medication.

• Xerese Cream is not authorized for use in children under 6 years of age.
• Apply only to the lips and surrounding mouth area only, and avoid contact with the eyes, inside of the nose, mouth, and genital region.
• Only use this medication longer than 2 weeks

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Changes in skin color
• Skin redness
• Itching
• Dryness or scaling
• Mild burning or stinging at the application site

Serious side effects may include:
• Difficulty breathing
• Blistering
• Intense redness or pain
• Hives

Please note that this is not an exhaustive list of possible side effects, and other reactions may also happen. For personalized advice and comprehensive information, speak with your healthcare provider.

Is it safe to take it with another drug?

While no major interactions are expected with the topical use of Xerese, it's important to inform your doctor about all medications, supplements, and skin products you use and to avoid applying other topical products to the same area unless directed by your healthcare provider.

How should I store it?

Xerese Cream should be kept in its original container and stored at room temperature, ideally between 20°C and 25°C (68°F to 77°F), to maintain its effectiveness. Be sure to protect it from excess heat, moisture, and light, and keep it out of reach of children and pets. Always check the packaging for specific storage instructions and never use it past its expiration date.

What action should I take in case of overdose?

Overdose from topical use of Xerese Cream is unlikely due to minimal systemic absorption. However, if large amounts are accidentally ingested or applied excessively, discontinue use and seek immediate medical attention. Symptoms of overdose may include increased skin irritation, burning, stinging, or redness at the application site, and in rare cases, systemic effects such as headache or nausea.

Is it safe for pregnant or breastfeeding women?

Xerese Cream (Acyclovir/Hydrocortisone) is classified as FDA Pregnancy Category B, indicating that animal studies have not demonstrated harm to the fetus, although adequate studies in pregnant women are lacking. Systemic absorption from topical application is minimal. Nonetheless, caution is advised when using Xerese during pregnancy or breastfeeding.

It is unknown whether the medication passes into breast milk, so consult your healthcare provider to evaluate potential risks and benefits before use.

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