Why is Zanaflex prescribed?

Tizanidine (Zanaflex) is prescribed alone or in combination with other medications for the treatment of spasticity of muscles, sclerosis and cerebral palsy.

What does it do?

Tizanidine, classified as an alpha adrenergic agonist, is a muscle relaxant medication which primarily works by increasing the blockage of motor neuron in the presynaptic nerves; thus, blocking impulses in the nerve and relaxes the muscle.

How should I take it?

Zanaflex and its generic equivalents are available as 2mg and 4mg tablets. It is intended for oral administration as a whole, not to be crushed or chewed, and should be taken with or without food as directed by the doctor.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is strictly advised that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

Taking the dose properly at the scheduled time is needed to attain the desired effect of the drug. If you miss a dose, take it as soon as you remember. However, if it is near the time of the next dose, skip the missed dose and catch the next dose at the regular time. Do not take two doses just to make up for your missed dose.

What are the special precautions before taking Zanaflex?

Before taking Tizanidine, tell your doctor or pharmacist if you have any allergies to food or to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

Inform your doctor about your past and current medical history especially if you have or have had liver disease, heart problems, dysrhythmia, kidney disease, high blood pressure, rebound hypertension, hypotension, and hypertonia.

Avoid drinking alcohol as this may cause dizziness or drowsiness which can add to the effects of Tizanidine.

Consult your doctor regarding all the other medications you use before getting a surgery.

For the drug label information of Zanaflex, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Abnormal liver function test
• Constipation
• Dizziness
• Dry mouth
• Fatigue
• Flu symptoms
• Heartburn
• Nausea
• Slurred speech
• Uncontrolled muscle movement
• Urinary tract infection
• Vision problems
• Vomiting

Serious side effects may include:
• Angina
• Dysrhythmia
• Hallucinations
• Hives
• Jaundice
• Jaw pain
• Myocardial infarction
• Shoulder pain
• Syncope
• Tachycardia

Is it safe to take it with another drug?

Some drug interactions may cause serious or life-threatening reactions when administered together. Immediately inform your doctor if you are taking Zanaflex with any of the following medications:

• Abametapir
• Amobarbital
• Avalide
• Benicar
• Candez
• Carbatrol
• Catapres
• Cipralex
• Cipro
• Clobazam
• Cozaar
• Diovan
• Dormicum
• Eprosartan
• Erythromycin
• Givosiran
• Irbesartan
• Isoniazid
• Isoptin
• Lexapro
• Lifezar
• Luvox
• Mefloquine
• Mexiletine
• Micardis
• Modafinil
• Mysoline
• Pefloxin
• Tagamet
• Telmisartan

If you are using any prescription, non-prescription, and herbal medications, inform your doctor and pharmacist for proper information and ask for other possible interactions not listed within this section.

How should I store it?

Store Zanaflex at room temperature (25°C) in a clean environment away from light and moisture. Do not refrigerate. Keep away from children. Do not remove the desiccant in the original container. Throw away if unused or expired. Do not flush in the toilet. Consult the pharmacist for proper disposal.

What should I do in case of an overdose?

If you suspect an overdose, immediately call an ambulance and seek immediate medical attention to prevent further complications.

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Tizanidine to determine drug-associated risks of major maternal defects, miscarriages and fetal outcomes. However, as per US FDA, Tizanidine is categorized as Pregnancy Category C which states that no potential harm and well-controlled studies have been done in humans; but animal studies have shown adverse effects on the fetus.

The presence of Tizanidine in human milk is still unknown.

The use of Tizanidine in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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