Why is Zaxine prescribed?

Rifaximin (Zaxine) is being prescribed to stop the growth of bacteria known as E. coli to patients experiencing irritable bowel syndrome such as abdominal cramps and diarrhea. Moreover, it is being used to treat liver diseases such as hepatic encephalopathy.

What does it do?

Eating and drinking contaminated food and drinks often lead to a higher risk of developing intestinal infection. This infection may involve pain in the gastrointestinal tract and may cause irritable bowel syndrome and diarrhea. Some antibacterial medications help in the treatment of such diseases and one of these is Rifaximin.

Rifaximin is classified as an antibacterial and anti-diarrheal agent that works by inhibiting the synthesis of protein causing irreversible blockage to the bacterial DNA-dependent RNA enzyme, thus, inhibiting the growth of bacteria and toxins in the intestine and in the liver.

How should I take it?

Zaxine is available as a 550mg tablet that is intended for oral administration as a whole, not to be crushed or chewed, and should be taken with or without food.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is strictly advised that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

Taking the dose properly at the scheduled time is needed to attain the desired effect of the drug. If you miss a dose, take it as soon as you remember. However, if it is near the time of the next dose, skip the missed dose and catch the next dose at the regular time. Do not take two doses just to make up for your missed dose.

What are the special precautions before using Zaxine?

Before taking Rifaximin, tell your doctor or pharmacist if you have any allergies to food and to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

Inform your doctor about your past and current medical history especially if you have or have liver disease and biliary cirrhosis, bloody and watery diarrhea. In addition, advise your doctor before getting immunizations and/or vaccinations as it may interfere its effect and may cause live bacterial vaccines.

Rifaximin is not intended for bloody diarrhea and other diarrheal causative agents such as Campylobacter jejuni, Clostridium difficile, Shigella and Salmonella species.

Consult your doctor regarding all the other medications you use before getting a surgery.

For the drug label information of Rifaximin, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Abdominal pain
• Bloating
• Chills
• Dizziness
• Fatigue
• Fever
• Headache
• Muscle pain
• Swelling of hands and feet

Serious side effects include:
• Bloody stool
• Dysphagia
• Dyspnea
• Hives
• Hoarseness
• Itching
• Loss of taste
• Rash
• Rectal tenesmus
• Tachycardia

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Zaxine with any of the following medications:

• Adalat
• Azithromycin
• Biaxin
• Carvedilol
• Chorella vaccine
• Cordarone
• Coumadin
• Crizotinib
• Dipyridamole
• Eliglustat
• Erythromycin
• Inderal
• Isoptin SR
• Itraconazole
• Jantoven
• Mefloquine
• Nicardipine
• Nizoral
• Nolvadex
• Posaconazole
• Quinidine
• Ranolazine
• Ritonavir
• Restasis
• Saquinavir
• Vandetanib

If you are using of any prescription, non-prescription and herbal medications, inform your doctor and pharmacist for proper information and ask for other possible interactions not listed within this section.

How should I store it?

Store Zaxine in room temperature (25°C) in a clean environment away from light and moisture. Do not refrigerate. Keep away from children. Do not remove the desiccant in the original container. Throw away if unused or expired. Do not flush in the toilet. Consult the pharmacist for proper disposal.

What action should I take in case of overdose?

If you suspect an overdose, immediately call an ambulance and seek immediate medical attention to prevent further complications.

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Rifaximin to determine drug-associated risks of major maternal defects, miscarriages and fetal outcomes. However, as per USA FDA, Rifaximin is categorized as Pregnancy Category C which states that no potential and well-controlled studies done in humans, but animal studies have shown adverse effects on the fetus.

The presence of Rifaximin in human milk is still unknown. It is better to consult your doctor first before breastfeeding.

The use of Rifaximin in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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