Why is Zestril prescribed?

Lisinopril (Zestril) is prescribed for the treatment of hypertension that may cause myocardial infarction, stroke and other heart problems.

What does it do?

Lisinopril, an Angiotension Converting Enzyme (ACE) inhibitor, is an anti-hypertensive agent that primarily works by inhibiting the conversion of Angiotensin I to Angiotensin II, which is responsible for constriction of the blood vessels; thus, helping the blood flow smoothly through relaxation of the blood vessels.

How should I take it?

Zestril and its generic equivalents are available as 2.5mg, 5mg, 10mg, 20mg and 40mg tablets. It is intended for oral administration as a whole, not to be crushed or chewed, and should be taken once daily with or without food as directed by the doctor.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is strictly advised that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

Taking the dose properly at the scheduled time is needed to attain the desired effect of the drug. If you miss a dose, take it as soon as you remember. However, if it is near the time of the next dose, skip the missed dose and catch the next dose at the regular time. Do not take two doses just to make up for your missed dose.

What are the special precautions before taking Zestril?

Before taking Lisinopril, tell your doctor or pharmacist if you have any allergies to food or to the drug itself as it may contain several inactive ingredients, which can cause allergic reactions or problems.

Inform your doctor about your past and current medical history especially if you have or have had swelling of the face and skin, high level of potassium in the blood, angioedema and dialysis.

Avoid drinking alcohol as this may cause dizziness and drowsiness and can add to the effects of Lisinopril.

Consult your doctor regarding all the other medications you use before getting surgery.

For the drug label information of Zestril, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Constipation
• Dizziness
• Dry cough
• Fatigue
• Gas
• Light-headedness

Serious side effects may include:
• Alopecia
• Asthenia
• Bone marrow depression
• Diabetes Mellitus
• Epidermal necrosis
• Gout
• Hemolytic anemia
• Leukopenia
• Myalgia
• Pruritus
• Steven Johnson syndrome
• Taste disturbance
• Urticaria

Is it safe to take it with another drug?

Some drug interactions may cause serious or life-threatening reactions when administered together. Immediately inform your doctor if you are taking Lisinopril with any of the following medications:

• Advil
• Alfuzosin
• Aliskiren
• Aluminum hydroxide
• Amifostine
• Aspirin
• Atacand
• Avalide
• Benicar
• Cataflam
• Carbidopa
• Cardura
• Celebrex
• Diabeta
• Diovan
• Eprosartan
• Feldene
• Glumetza
• Indocinli>
• Ketorolac
• Levodopa
• Losartan
• Lifezar
• Metaglip
• Mobic
• Naproxen
• Oxaprozin
• Pregabalin
• Skelan
• Telmisartan

If you are using of any prescription, non-prescription and herbal medications, inform your doctor and pharmacist for proper information and ask for other possible interactions not listed within this section.

How should I store it?

Store Zestril in room temperature (25 °C) in a clean environment away from light and moisture. Do not refrigerate. Keep away from children. Do not remove the desiccant in the original container. Throw away if unused or expired. Do not flush in the toilet. Consult the pharmacist for proper disposal.

What action should I take in case of overdose?

If you suspect an overdose, immediately call an ambulance and seek immediate medical attention to prevent further complications.

Is it safe for pregnant or breastfeeding women?

There are only limited studies and data regarding the safety of Lisinopril to determine drug-associated risks of major maternal defects, miscarriages and fetal outcomes. However, during the second and third trimester of pregnancy, reduction of fetal renal function and an increase of fetal mortality are seen.

The presence of Lisinopril in human milk is still unknown. Consult your doctor before breastfeeding.

The use of Lisinopril in pregnant and breastfeeding women should be avoided unless the potential benefits outweigh the risks.

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