NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Circadin prescribed?

Circadin (Melatonin) is used to enhance sleep quality and morning alertness in individuals who experience poor sleep.

What does it do?

The active ingredient in Circadin, melatonin (which is not derived from plants or animals), is a naturally occurring hormone produced by the body. Melatonin helps regulate circadian rhythms and promotes good sleep.

How should I take it?

The recommended dose is one tablet taken orally once a day, after a meal, 1-2 hours before bedtime. This dosage can be maintained for up to thirteen weeks. Swallow the tablet whole; do not crush or split it. Always follow your doctor’s or pharmacist’s instructions.

What if I missed a dose?

If you miss a dose, take it as soon as you remember, before going to bed. If it's almost time for your next dose, skip the missed dose and continue as usual. Do not take two doses to make up for a missed one.

What are the special precautions before taking Circadin?

Inform your doctor about all the medications you are taking, your current and previous medical history.

• You have any allergies to medicines and to its ingredients.
• You are pregnant or planning to become pregnant.
• You are breastfeeding or planning to breastfeed.
• Liver problems
• Kidney problems
• An autoimmune disease
• A rare inherited condition such as LAPP lactase deficiency, galactose intolerance, or glucose-galactose malabsorption.
Do not give to children or adolescents, as there is no experience with its use in individuals under 18 years of age and if you have been drinking alcohol, plans or suspect alcohol may be in your bloodstream.
Does it have any side effects?

If you feel unwell while taking Circadin, contact your doctor or pharmacist as soon as possible. Although Circadin has been shown to improve sleep for most people over 55, it may cause unwanted side effects in some individuals. All medications can have side effects, some of which may be serious, but most are not. If you experience any side effects, you may need medical attention.

Common side effects may include:
• Irritability
• Dizziness
• High blood pressure
• Headaches
• Nervousness
• Nightmares
• Migraines
• Tiredness
• Upper abdominal pain
Rare side effects may include:
• Abnormal bowel sounds
• Gastroesophageal reflux
• Flatulence
• Excessive saliva production
• Gastrointestinal issues
• Mouth blisters
Other side effects not listed above may also occur in some patients. If you notice any other effects, inform your doctor.
Is it safe to take it with another drug?
Inform your doctor if you are taking any other medications, including those available without a prescription as certain medicines may interact with Circadin.
• Alcohol
• Caffeine
• Hypnotics and tranquilizers (e.g., Benzodiazepines)
• Estrogen (such as contraceptives or hormone replacement therapy)
• Cimetidine and Psoralens (used for skin conditions like psoriasis)
• Thioridazine, Fluvoxamine, and Imipramine (used to treat depression or psychiatric conditions)

The effects of combining Circadin with other insomnia treatments have not been studied. It is unclear whether Circadin will enhance or reduce the effects of other insomnia medications.

Your doctor or pharmacist can provide more information about which medications to be cautious with or avoid while taking Circadin.

How should I store it?
Keep your tablets in the blister pack until you're ready to take them. Store Circadin away from sunlight in a cool, dry place, with a temperature not exceeding 25°C.
What action should I take in case of overdose?
If you take too much Circadin, immediately contact your doctor or go to the nearest accident and emergency center. Do this even if you or someone else does not show any signs of discomfort or poisoning.
Is it safe for pregnant or breastfeeding women?
Do not take Circadin if you are pregnant or breastfeeding, as it has not been studied in these populations. If you become pregnant while taking Circadin, stop taking the tablets and contact your doctor right away.
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