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Why is Kombiglyze XR prescribed?

Kombiglyze XR (Saxagliptin/Metformin) Extended-release Tablets is a combination medication used to treat type 2 diabetes in adults, alongside diet and exercise. It is not intended for individuals with diabetic ketoacidosis or type 1 diabetes.

What does it do?

Metformin helps lower blood sugar by reducing glucose production in the liver and limiting its absorption in the intestines. Saxagliptin works by regulating insulin production in the body after meals. Kombiglyze XR is used, along with diet and exercise, to help control blood sugar levels in adults.

How should I take it?

Take Kombiglyze XR with food once a day preferably in the evening, following your doctor's instructions. With gradual dose titration to reduce gastrointestinal side effects due to metformin HCl and maybe modified due to your condition.

What if I missed a dose?

If you miss a dose, skip it and take your next dose at the usual time. Do not take two doses or extra medication.

What are the special precautions before taking Kombiglyze XR?

You should not use Kombiglyze XR if you have severe kidney disease or diabetic ketoacidosis (in which case, contact your doctor for insulin treatment).

Tell your doctor if you have a history of:

• Liver disease
• Heart disease
• Pancreatitis
• Gallstones
• Alcoholism
• High triglycerides
• Kidney disease

Kombiglyze XR may cause lactic acidosis, a serious build-up of lactic acid in the blood, which could be more likely if you have chronic alcoholism, a severe infection, other health conditions, or are 65 or older. Ask your doctor about your risk.

If you need surgery or an x-ray/CT scan with a dye injected into your veins, you may need to temporarily stop taking Kombiglyze XR. Make sure your healthcare providers know in advance that you are using this medication.

Follow your doctor's guidance regarding the use of Kombiglyze XR if you are pregnant or breastfeeding. Blood sugar control is crucial during pregnancy, and your dosage may change throughout the pregnancy. Your dosage may also need adjustment while breastfeeding.

Does it have any side effects?

If you experience symptoms of pancreatitis, such as vomiting, loss of appetite, severe upper stomach pain radiating to your back, nausea, or rapid heartbeats, stop taking Kombiglyze XR and contact your doctor immediately.

Metformin can cause lactic acidosis, a potentially life-threatening condition. Seek emergency medical help if you notice even mild symptoms like unusual muscle pain, feeling cold, trouble breathing, dizziness, extreme fatigue, stomach pain, vomiting, or an irregular heartbeat.

Serious side effects may include:
• Ongoing joint pain
• Pain or burning during urination
• Severe allergic reaction (itching, blisters)
• Symptoms of heart failure (shortness of breath, swelling in legs/feet)

Common side effects may include:
• Nausea
• Headache
• Diarrhea
• Cold-like symptoms (runny/stuffy nose, sore throat).

This is not a complete list of side effects. Contact your doctor for further advice on managing side effects.

Is it safe to take it with another drug?

Kombiglyze XR can interact with many other medications, which may reduce their effectiveness or increase the risk of lactic acidosis.

Inform your doctor about all the medications you are taking, especially:

• Antibiotics or antifungal medicines
• Insulin or oral diabetes medications
• Medications for treating HIV or AIDS

This is not a complete list. Other drugs, including prescription and over-the-counter medicines, vitamins, and herbal supplements, may also interact with Kombiglyze XR. Not all possible interactions are listed here.

How should I store it?

Store Kombiglyze XR at room temperature, between 68°F and 77°F (20°C to 25°C). Keep it in a cool, dry place.

What action should I take in case of overdose?

Get emergency medical help for over dosage management.

Is it safe for pregnant or breastfeeding women?

Inform your doctor if you are pregnant or planning to become pregnant while using Kombiglyze XR, as it is not expected to harm a fetus. It is unclear whether Kombiglyze XR passes into breast milk or could affect a breastfeeding baby. Consult your doctor before breastfeeding.

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