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Why is Nexavar prescribed?

Some types of cancer in adults can be treated with Nexavar (Sorafenib). These include hepatocellular carcinoma (HCC) when the tumor can't be removed surgically, advanced renal cell carcinoma (RCC) when the cancer has spread to other parts of the body, and differentiated thyroid carcinoma (DTC) that has come back or spread after radioactive iodine treatment.

What does it do?

Nexavar (Sorafenib) works by inhibiting multiple kinases, which are enzymes crucial for regulating cell division and growth. By blocking these enzymes, Nexavar prevents tumor cell proliferation, inhibits angiogenesis (formation of new blood vessels), and induces apoptosis (programmed cell death), thereby disrupting the survival, growth, and spread of cancer cells.

How should I take it?

Nexavar (Sorafenib) should be taken exactly as prescribed by your healthcare provider. The typical dose is 400 mg orally twice daily. It's important to take it on an empty stomach, either 1 hour before or 2 hours after a meal.

Your doctor will monitor you regularly for side effects and may adjust your dose if needed. It's crucial to attend all scheduled appointments and report any side effects immediately.

What if I missed a dose?

If you miss a dose of Nexavar, take the missed dose as soon as you remember. If it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Never take a double dose to make up for a missed one, as this can increase the risk of side effects.

What are the special precautions before taking Nexavar?

Before taking Nexavar (Sorafenib), it's important to take certain precautions to ensure your safety and the effectiveness of the medication. Here are some key points to keep in mind:

• Tell your doctor if you have any history of heart problems, chest pain, high blood pressure, bleeding disorders, or liver disease.
• Make sure you are not allergic to Sorafenib or any of the ingredients in Nexavar.
• Nexavar can harm an unborn baby or cause birth defects. Women should not use Nexavar if they are pregnant.
• Tell your doctor about all medications, supplements, and herbal products you are taking, as Nexavar can interact with other drugs.
• If you are planning to have surgery, inform your surgeon or dentist that you are taking Nexavar. You may need to stop taking it at least 10 days before the procedure.
• Regular monitoring of your blood pressure and other health parameters is necessary while taking Nexavar

It's crucial to follow your doctor's instructions and attend all scheduled appointments to monitor your health and adjust the treatment if needed.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Acne
• Easy bruising or bleeding
• Skin rashes
• Dry skin
• Nausea
• Fatigue
• Thinning or patchy hair loss
• Weight loss

Serious side effects may include:
• Blood in urine or stools
• Irregular heartbeat
• Chest pain
• Severe stomach pain
• Sudden vision loss
• Yellowing of the skin or eyes

The list above does not cover all of the potential side effects, and others may occur. For further information on side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Nexavar (Sorafenib) can interact with many other medications, which can either increase the risk of side effects or affect how well Nexavar works. Nexavar has different levels of drug interactions:

• Major Interactions: Nexavar can have severe interactions with drugs like dronedarone, pimozide, and thioridazine, and these combinations should generally be avoided.
• Moderate Interactions: Several medications, such as warfarin, dexamethasone, and rifampin, may have moderate interactions, requiring dose adjustments or close monitoring.
• Minor Interactions: Nexavar also has minor interactions with drugs like ketoconazole and levoketoconazole, which still need to be considered.
How should I store it?
Store Nexavar at room temperature between 20°C to 25°C (68°F to 77°F), away from moisture and direct sunligh. Keep Nexavar in its original container to protect it from light and humidity, and avoid storing it in the bathroom. Lastly, keep the medication out of reach of children and pets to prevent accidental ingestion.
What action should I take in case of overdose?
In case of an overdose with Nexavar (Sorafenib), it's important to seek medical attention immediately. Contact emergency services or go to the nearest hospital right away.
Is it safe for pregnant or breastfeeding women?

Nexavar (Sorafenib) is not safe for pregnant or breastfeeding women. Nexavar can cause harm to an unborn baby and may lead to birth defects. Women should not use Nexavar if they are pregnant. If pregnancy occurs while taking Nexavar, it's important to inform your doctor immediately.

For breastfeeding, Nexavar can pass into breast milk and may harm a nursing infant. Breastfeeding should be avoided while taking Nexavar and for at least 2 weeks after the last dose. Both men and women of childbearing potential should use effective birth control during treatment with Nexavar and for at least 2 weeks after the last dose.

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