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Why is Olumiant prescribed?

Olumiant B(aricitinib) is prescribed for several conditions such as rheumatoid arthritis, severe alopecia areata (hair loss) and COVID-19 that needs breathing support.

What does it do?

Olumiant (Baricitinib) works by targeting the immune system to reduce inflammation. It specifically blocks an enzyme called Janus kinase (JAK), which plays a key role in signaling pathways that trigger immune responses. By inhibiting JAK, Olumiant helps to calm overactive immune activity, which is a common factor in conditions like rheumatoid arthritis, alopecia areata, and severe inflammation during illnesses like COVID-19.

How should I take it?

Olumiant is usually taken as a daily oral tablet and can be consumed with or without food, and make sure to not chew, break, or crush Olumiant tablets. The dose may vary depending on the condition being treated:

• For rheumatoid arthritis, the usual dose is a 2 mg tablet daily, but your doctor may adjust this based on your specific needs.
• For alopecia areata, the usual dose is a 2 mg tablet daily, but for severe cases, it can go up to 4 mg daily.
• For severe COVID-19, the usual dose is 4 mg daily for a limited duration.

What if I missed a dose?

If you miss a dose of Olumiant, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

What are the special precautions before taking Olumiant?

Inform your doctor about all the medications you are taking, your current and previous medical history.

• Blood clots
• Heart problems, such as a previous heart attack or stroke
• Cancer or a weakened immune system
• Liver or kidney disease
• Tuberculosis or other infections

Avoid live vaccines while taking Olumiant and be sure to discuss your vaccination history with your doctor.

Olumiant is not recommended during pregnancy or breastfeeding due to potential risks to the baby.

If you are a current or past smoker, discuss this with your doctor, as it may increase certain risks.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Cold sores or shingles
• Fatigue
• Nausea
• Sneezing, sore throat, or stuffy nose
• Headache
• Weight gain

Serious side effects may include:
• Blood clots
• Cancer and immune system problems
• Serious infections such as tuberculosis, or fungal infections
• Swelling of your lips, tongue, or throat
• Cardiovascular issues such as stroke or heart attack

This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Olumiant can interact with other medications, and some combinations may not be safe. Make sure to inform your healthcare provider about all the medications you are using.

It is not recommended to use Olumiant with other medications below:

• JAK inhibitors
• Biologic disease-modifying antirheumatic drugs (DMARDs)
• Live Vaccines
• NSAIDs (nonsteroidal anti-inflammatory drugs)
• Steroid medicines

How should I store it?

Olumiant should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F to 77°F). Keep it away from direct sunlight and out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Olumiant, it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital.

Is it safe for pregnant or breastfeeding women?

Olumiant is generally not recommended for use during pregnancy or breastfeeding. While there isn't enough human data about the effects of Olumiant on pregnancy or an unborn baby, experts advise against using Olumiant during pregnancy unless the benefits outweigh the risks. Tell your healthcare provider if you are pregnant or planning to become pregnant before using this medication.

It is also unknown if Olumiant passes into breast milk. To avoid potential risks to the infant, breastfeeding while using Olumiant is discouraged.

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