NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Ongentys prescribed?

Ongentys (Opicapone) is prescribed as an adjunctive treatment for people with Parkinson's disease who are experiencing "off" episodes. A condition that affects the part of your brain that controls your movements when the effects of their primary medication (levodopa/carbidopa) wear off, leading to symptoms like stiffness, tremors, or poor muscle control.

What does it do?

Ongentys (Opicapone) works by inhibiting the enzyme called catechol-O-methyltransferase (COMT), which is responsible for breaking down levodopa in the body. By doing so, it helps extend the action of levodopa, ensuring that its effects last longer. This allows for better control of Parkinson's disease symptoms, especially during "off" periods when levodopa’s effects wear off.

How should I take it?

Ongentys (Opicapone) is usually taken as a once-daily oral capsule at bedtime, at least 1 hour after eating, since food can affect its absorption. The standard dose is 50 mg per day, but your doctor will determine the appropriate dose based on your specific needs and condition.

What if I missed a dose?

If you miss a dose of Ongentys, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

What are the special precautions before taking Ongentys?

Before taking Ongentys, here are several important precautions to consider:

Make sure to tell your healthcare provider about your medical history, especially if you have experienced:

• Liver or kidney disease
• Cardiovascular issues, such as arrhythmias or high blood pressure
• Tumors like pheochromocytoma or paraganglioma
• Sleep disorders
• Mental health conditions

Do not take Ongentys if you are allergic to Opicapone or any of the other ingredients in the medication.

Refrain from driving or operating machinery while taking Ongentys, as it may cause drowsiness or sudden sleep episodes.

Regular blood pressure checks and monitoring for any side effects like involuntary movements or drowsiness upon standing are recommended.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Constipation
• Involuntary movements such as dyskinesia
• Low blood pressure upon standing (Orthostatic Hypotension)
• Weight loss
• Increased creatine kinase levels
• Dizziness

Serious side effects may include:
• Difficulty breathing
• Swelling of the face or throat, and hives
• Cardiovascular issues such as arrhythmias
• Unusual or Compulsive Behaviors

This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Before starting Ongentys, it's important to inform your healthcare provider if you are taking any of the following:

• Medications for Parkinson’s disease, such as levodopa/carbidopa.
• Non-Selective Monoamine Oxidase (MAO) inhibitors, often prescribed for depression or certain neurological conditions.
• Other medications that affect dopamine levels.

It's important to always tell your healthcare provider about all medications, supplements, or herbal products you're taking to ensure safety and avoid harmful drug interactions.

How should I store it?

Ongentys should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F to 77°F). Keep it away from direct sunlight and out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Ongentys, it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital.

Is it safe for pregnant or breastfeeding women?

Ongentys (Opicapone) is generally not recommended for use during pregnancy or breastfeeding. There is insufficient data on its safety in pregnant women, but animal studies suggest potential risks, including fetal harm. As a precaution, it is advised to avoid Ongentys during pregnancy unless absolutely necessary.

For breastfeeding, it is unknown whether Ongentys passes into human breast milk, but it has been found in animal milk. To minimize potential risks to the infant, breastfeeding while using Ongentys is generally not recommended.

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