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Why is Orilissa prescribed?

Orilissa is prescribed to treat moderate to severe pain caused by endometriosis, a condition where tissue similar to the lining inside the uterus grows outside of it. It works by lowering levels of certain hormones, like estrogen, which fuel endometriosis pain. It’s not a cure for endometriosis, but it can help manage symptoms such as painful periods, pelvic pain between periods, and pain during intercourse.

What does it do?

Orilissa works by reducing the levels of estrogen in the body, which is a hormone that fuels the growth of endometriosis lesions. It achieves this by blocking a specific hormone signal in the brain that stimulates the ovaries to produce estrogen. By lowering estrogen levels, Orilissa helps to reduce the pain associated with endometriosis.

How should I take it?

Orilissa is typically taken as a daily pill, and the dosage depends on your treatment goals. Take 150mg once daily for up to 24 months or 200mg twice daily for up to 6 months. It's important to follow your doctor's instructions and take Orilissa every day, even if you're feeling better. This medication works throughout your menstrual cycle, so consistency is key.

How should I take it?

If you miss a dose of Orilissa, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

What are the special precautions before taking Orilissa?

Inform your doctor about all the medications you are taking, your current and previous medical history.

• Do not take Orilissa if you are allergic to Elagolix or any of the other ingredients in the medication.
• Orilissa can lower estrogen levels, which may lead to bone loss (osteoporosis). Discuss ways to maintain bone health with your doctor.
• Avoid using Orilissa (Elagolix) if you are pregnant, have osteoporosis, or have severe liver disease.
• Change in mood or even suicidal ideation may occur while using this medication
• Hormonal birth control methods may reduce Orilissa's effectiveness. Use non-hormonal methods like condoms or diaphragms with spermicide.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Hot flashes or night sweats
• Headache
• Nausea
• Insomnia or difficulty sleeping
• Mood changes including depression or anxiety
• Joint pain
• Lack of periods (amenorrhea)

Serious side effects may include:
• Weak bones (osteoporosis)
• Suicidal thoughts or behavior
• Severe allergic reactions, such as swelling of the face, lips, or throat
• Difficulty breathing or swallowing
• Severe abdominal pain or cramping

This is not a complete list of all possible side effects, and others may occur. For more information about side effects, please consult your healthcare provider.

Is it safe to take it with another drug?

Orilissa (Elagolix) may interact with other medications, so it's important to take caution before combining it with other drugs. Medications like cyclosporine or gemfibrozil can significantly increase the risk of side effects, and certain antibiotics, hormonal birth control, or proton pump inhibitors may affect how Orilissa works.

• Combined hormonal contraceptives
• Digoxin
• Benzodiazepines
• Rosuvastatin
• Omeprazole

Always seek medical advice from your healthcare provider before using Orilissa alongside other medications to ensure it is safe and effective.

How should I store it?

Orilissa should be stored in its original container at room temperature, ideally between 20°C and 25°C (68°F and 77°F). Keep it away from direct sunlight and out of reach of children and pets.

What action should I take in case of overdose?

If you suspect an overdose of Orilissa (Elagolix), it's important to act quickly and seek immediate medical attention. Contact emergency services or go to the nearest hospital. While waiting for help, monitor for any signs of adverse reactions, such as severe abdominal pain, difficulty breathing, or unusual mood changes.

Is it safe for pregnant or breastfeeding women?

Orilissa is not safe during pregnancy and may cause miscarriage. A negative pregnancy test is required before starting treatment. For breastfeeding women, the safety of Orilissa is uncertain and it is not known whether the drug passes into breast milk or affects the breastfed child. It's important to consult your doctor if you're pregnant or breastfeeding before using the medication to ensure safety.

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