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Why is Sinequan prescribed?

Sinequan (Doxepin) is a tricyclic antidepressant prescribed to treat depression and anxiety. Additionally, Sinequan may be used for insomnia under the brand name Silenor. However, it is not a first-choice treatment due to potential side effects like drowsiness, dry mouth, and weight gain.

What does it do?

Sinequan (Doxepin) works by inhibiting the reuptake of serotonin and norepinephrine in the brain, increasing their levels and improving mood. It also blocks histamine (H1) receptors, which contributes to its sedative effects and makes it useful for treating insomnia.

How should I take it?

Sinequan (Doxepin) should be taken exactly as prescribed by your doctor. The dosage depends on the condition being treated. For depression and anxiety, the usual starting dose is 75 mg per day, which can be adjusted between 75 mg to 150 mg daily based on response. In severe cases, doses may go up to 300 mg per day, but exceeding this rarely provides additional benefits.

For insomnia, lower doses (such as 3 mg to 6 mg) are typically used, taken 30 minutes before bedtime. It can be taken once daily at bedtime or divided throughout the day, depending on your doctor's recommendation.

What if I missed a dose?

If you miss a dose of Sinequan, take it as soon as you remember. If your next dose is approaching, skip the missed one and continue following your usual schedule. Avoid taking extra or double doses to compensate for the missed dose.

What are the special precautions before taking Sinequan?

Before taking Sinequan, here are several important precautions to keep in mind:

• If you experience difficulty urinating or have glaucoma, consult your doctor before using this medication to ensure it is safe for you.
• Antidepressants like Sinequan may increase the risk of suicidal thoughts, especially in children, adolescents, and young adults. Close monitoring is essential, particularly when starting treatment.
• Avoid sharing this medication with others, even if they have a similar condition, as it may cause unexpected health risks or adverse effects.
• Avoid consuming alcohol while taking Sinequan, as it can increase drowsiness.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Blurred vision
• Drowsiness
• Dry mouth
• Constipation
• Weight changes

Serious side effects may include:
• Suicidal thoughts
• Irregular heartbeat or palpitations
• Swelling of the mouth, face, lips, tongue, or throat
• Urinary retention
• Worsened depression

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Sinequan can interact with various medications, so it's important to check for potential interactions before taking it with another drug. Some interactions may increase side effects or reduce effectiveness.

Before taking Sinequan, consult your doctor if you are using any of the following medications:

• Certain Antidepressants
• Monoamine Oxidase Inhibitors (MAOIs)
• Heart Medications
• Pain Relievers (NSAIDs, opioids)
• Antihistamines

This is not a complete list of all the potential drug interactions, always consult your doctor or pharmacist before combining Sinequan with other medications to ensure safety.

How should I store it?

Sinequan should be stored in its original container at room temperature, ideally between 15°C and 25°C (59°F to 77°F). Keep it away from direct sunlight and out of reach of children and pets.

Is it safe for pregnant or breastfeeding women?

Sinequan (Doxepin) should be used with caution during pregnancy and breastfeeding. Doctors typically prescribe doxepin during pregnancy only if the benefits outweigh the risks. For breastfeeding mothers, reports indicate it may cause drowsiness or breathing difficulties in nursing infants, leading some experts to recommend against its use due to potential risks.

If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider for guidance on its use to ensure safety for both you and your baby.

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