NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Vocabria prescribed?

Vocabria is prescribed for the treatment and prevention of HIV-1 infection:

• As part of a short-term oral lead-in regimen before switching to long-acting injectable therapy with cabotegravir and rilpivirine.
• As oral therapy for patients who will miss scheduled injections.
• For pre-exposure prophylaxis (PrEP) in HIV-negative individuals at risk of acquiring HIV-1.

What does it do?

Vocabria contains cabotegravir, an integrase strand transfer inhibitor (INSTI) that targets the HIV integrase enzyme, blocking the integration of viral DNA into the host genome. By disrupting this critical step in the viral life cycle, cabotegravir inhibits HIV replication, helping to maintain viral suppression and lower the risk of transmission.

How should I take it?

Always follow your doctor’s instructions, or the directions on the product label when taking this medication. Vocabria is taken as one 30 mg tablet orally once daily, typically in combination with rilpivirine 25 mg, and should be administered with a meal to ensure optimal absorption. It is used for approximately one month as a lead-in before initiating long-acting injectable therapy or as an oral replacement for missed injections for up to two months.

What if I missed a dose?

If a dose of Vocabria is missed, take it as soon as you remember, unless it's already close to the time for your next scheduled dose. In that case, simply skip the missed dose and continue with your regular dosing routine. Avoid taking additional or double doses, as this can increase the risk of adverse effects.

Consistently missing doses of Vocabria may reduce its long-term effectiveness, making it crucial to take each dose as prescribed without skipping.

What are the special precautions before taking Vocabria?

Before taking Vocabria, here are several important precautions to keep in mind:

• Do not take Vocabria if you're allergic to Cabotegravir or any of the ingredients in the medication.
• Disclose all your current or past medical conditions to your doctor, particularly if you have:
• Liver problems
• Kidney problems
• HIV
• History of mental health disorders
• Vocabria is not authorized for individuals under 12 years of age or those weighing less than 77 pounds (35 kilograms).
• Avoid sharing Vocabria with others even if their condition appears similar, as doing so may result in unexpected health risks or dangerous side effects.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects may include:
• Headache
• Nausea
• Diarrhea
• Dizziness
• Insomnia

Serious side effects may include:
• Difficulty breathing
• Yellowing of the skin or eyes (jaundice)
• Depression or suicidal thoughts
• Fever

This is not a complete list of potential side effects, and additional reactions may occur. For detailed information and medical guidance, consult your healthcare provider.

Is it safe to take it with another drug?

Vocabria (Cabotegravir) has the potential to interact with a wide range of medications, which can either heighten the risk of side effects or diminish its therapeutic effectiveness.

Before taking Vocabria, consult your doctor if you are using any of the following medications:

• Carbamazepine
• Rifampin
• Phenobarbital
• Rifabutin
• Oxcarbazepine

This is not a full list of possible drug interactions. To ensure your safety, it's essential to speak with your doctor or pharmacist before taking Vocabria alongside other medications, including over-the-counter drugs or supplements.

How should I store it?

Vocabria should be kept in its original container and stored at room temperature, ideally between 20°C and 25°C (68°F to 77°F), to maintain its effectiveness. Be sure to protect it from excess heat, moisture, and light, and keep it out of reach of children and pets.

What action should I take in case of overdose?

In case of a Vocabria (Cabotegravir) overdose, you should seek immediate medical attention by contacting your local emergency services or going to the nearest hospital. Overdose symptoms may include nausea, vomiting, dizziness, fatigue, and abnormal liver function.

Is it safe for pregnant or breastfeeding women?

Vocabria (Cabotegravir) should be used during pregnancy or breastfeeding only if the potential benefits outweigh the risks. Limited human data are available, and animal studies have not shown harm to fetal development. However, because cabotegravir is excreted in breast milk in animal studies, caution is advised when administering it to breastfeeding women. It is imperative to consult a healthcare professional to evaluate personal risk factors and identify the most appropriate and safe course of action.

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