NOTE: Depending on the supplier/strength selected, the products shipped may have different packaging.

Why is Akynzeo prescribed?

Akynzeo (Netupitant/Palonosetron) capsules, when used in combination with dexamethasone, are indicated for the prevention of both acute and delayed nausea and vomiting in adults undergoing initial and repeat courses of cancer chemotherapy. This includes, but is not limited to, chemotherapy regimens that are highly emetogenic.

What does it do?

Netupitant and Palonosetron work by inhibiting natural substances in the body, such as substance P (neurokinin 1) and serotonin, that trigger vomiting.

How should I take it?

Before starting Akynzeo (Netupitant/Palonosetron) and each time you receive a refill, read the patient information leaflet provided by your pharmacist. If you have any questions, consult your doctor or pharmacist. Take this medication orally, with or without food, as prescribed by your doctor, typically 1 hour before chemotherapy begins. Inform your doctor if you experience vomiting or nausea.

What if I missed a dose?

It is important to take each dose of this medication as directed. If you miss a dose, contact your doctor promptly for a new dosing schedule. Do not take two doses at once to make up for the missed one.

What are the special precautions before taking Akynzeo?

This medication may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Contact your doctor right away if you experience symptoms such as a rash, rapid heartbeat, fever, hives and shortness of breath.

All patients using this medication should be monitored as with certain drugs may lead to a serious condition called serotonin syndrome associated with hallucinations, seizures,nausea and vomiting, and advised to immediately discontinue.

Does it have any side effects?

Like all medications, this medicine may cause side effects, although not everyone experiences them. If any of the following side effects occur, they may require medical attention.

Common side effects may include:
• Constipation
• Headache
• Fatigue
• Unusual tiredness or weakness
• Flushing or redness of the skin
• Heartburn

Contact your doctor immediately if you experience:

• Agitation
• Confusion
• Dizziness
• Fever
• Hallucinations
• Muscle twitching
• Shivering
• Sweating
• Overactive reflexes
• Poor coordination
• Trembling or shaking

Your healthcare provider may also provide ways to prevent or reduce these side effects. Contact your healthcare provider if any of the following side effects persist, become bothersome, or if you have concerns about them.

Is it safe to take it with another drug?

While some medications should never be used together, others may be used in combination even if an interaction is possible. In such cases, your doctor may adjust the dosage or take other precautions. It is especially important for your healthcare provider to know if you are taking any of the medications listed below. The following interactions have been selected due to their potential significance, but this list may not be complete.

In some cases, combining this medication with the following medicines may not be recommended, but it might be necessary. If both are prescribed, your doctor may adjust the dose or frequency of one or both medications.

• Carbamazepine
• Chlorpheniramine
• Cilostazol
• Cisapride
• Diltiazem
• Docetaxel
• Dofetilide
• Oral contraceptives
• Repaglinide
• Rifabutin
• Rifampin
• Sunitinib
• Suvorexant
• Tacrolimus
• Tamoxifen
• Warfarin
• Zolmitriptan
• Zolpidem
Ask your doctor or pharmacist for other possible interactions not listed within this section.
How should I store it?
Store the medication in a tightly closed container at room temperature, away from heat, moisture, and direct sunlight. Do not allow it to freeze. Keep it out of reach of children.
What action should I take in case of overdose?
If someone overdoses and experiences serious symptoms, such as loss of consciousness or difficulty breathing, seek immediate medical help by calling emergency services or going to the nearest emergency room.
Is it safe for pregnant or breastfeeding women?
This medication should be used during pregnancy only if prescribed by your doctor. It is not known whether this drug passes into breast milk. Consult your doctor before breastfeeding.
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