Why is Casodex  prescribed?

Bicalutamide (Casodex) is prescribed in combination with a gonadotropin-releasing hormone agonist for the treatment of prostate cancer that has metastasized or spread to other parts of the body. It should not be taken on its own or with other medications.

What does it do?

In cancer, abnormal cells in the body develop and grow uncontrollably and are able to destroy normal cells. Prostate cancer is a type of cancer in males affecting the prostate (a gland that produces semen) and can cause signs and symptoms such as blood in semen, pelvic discomfort, and problems during urination.

Casodex belongs to a drug class called non-steroidal anti-androgens and it works by inhibiting the activity of androgens (sex hormones) to stop cancer cells from growing and spreading to other parts of the body.

How should I take it?

Casodex and its generic equivalents are currently available in 50mg and 150mg tablets. Each tablet should be taken as a whole (do not split) by mouth with or without food.

The dosage strength depends on every patient’s condition and the doctor’s prescription. It is imperative that you do not self-medicate and only take this drug after consulting with your doctor or pharmacist to determine the best dosage and dosing schedule for the treatment of your condition.

What if I missed a dose?

The desired effects of prescribed medications will only be achieved if taken properly. As much as possible, strictly follow your doctor’s prescribed dosing schedule. However, if you miss a dose, take it immediately and adjust the time of your next dose depending on your doctor’s advice. Never take two doses at the same time just to make up for your missed dose.

What are the special precautions before using Casodex?

Inform your doctor about all the medications you are taking, your current and previous medical history, and any allergic reactions to Casodex or any other ingredients included in the manufacture of this medication.

Consult your doctor for effective methods of birth control. If a woman is exposed to Casodex through a male partner and becomes pregnant, it may cause harm to the fetus. Inform your doctor immediately if your partner becomes pregnant.

Casodex should only be taken by men and should never be taken by women or children.

For the drug label information of Casodex, click here.

Does it have any side effects?

It is important to note that all drugs have corresponding side effects and adverse reactions. Additional information may be obtained when you ask your doctor or pharmacist.

Common side effects include:
• Constipation
• Diarrhea
• Dizziness
• Frequent urination at night
• Hot flashes
• Nausea
• Weakness

Serious side effects include:
• Bleeding or bruising
• Blood in urine
• Blurry vision
• Body pain
• Chest pain
• Dark-colored urine
• Extreme fatigue
• Loss of appetite
• Painful and enlarged breasts
• Shortness of breath
• Stomach pain (right upper part)
• Yellowing of the skin or eyes

Is it safe to use it with another drug?

Some drug interactions may cause life-threatening reactions when taken with other medications. Immediately inform your doctor if you are taking Casodex with any of the following medications:

• Abilify
• Alprazolam
• Betapace
• Biaxin
• Buspirone
• Cardizem
• Celexa
• Chlorpheniramine
• Cordarone
• Coumadin
• Desyrel
• Diazepam
• Droperidol
• Erythromycin
• Geodon
• Indinavir
• Isoptin
• Lipitor
• Methadone
• Mevacor
• Midazolam
• Mifepristone
• Nisoldipine
• Nolvadex
• Norvasc
• Pimozide
• Plendil
• Procardia
• Prograf
• Quinidine
• Quinine
• Restasis
• Ritonavir
• Saquinavir
• Sparfloxacin
• Telithromycin
• Terfenadine
• Triazolam
• Viagra
• Vincristine
• Zocor

Ask your doctor or pharmacist for other possible interactions not listed within this section.

How should I store it?

Store Casodex in a tight container in a clean environment away from excessive heat and moisture. Keep out of reach of children.

What action should I take in case of overdose?

Immediately call an ambulance and seek immediate medical attention to prevent further complications or possible death.

Is it safe for pregnant or breastfeeding women?

Present data suggest that the use of Casodex in pregnant women is contraindicated. It should not be taken when pregnancy is confirmed as it can cause harm to the fetus.

There is also limited data on the presence of Casodex in human milk or its effects on the breastfed infant. The potential risks of using Casodex outweigh the potential benefits and it should not be taken by pregnant and breastfeeding women.

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